Protein: AGK
Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)

Gene: AGK
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q53H12

Gene Ontology (top 5):
GO:0001729 - ceramide kinase activity
GO:0004143 - ATP-dependent diacylglycerol kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199825

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

4

0

Small-scale

0.849

High

1199854

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

3

0

Small-scale

0.816

High

967257

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

3

0

High-throughput

0.811

High

563861

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.691

High

1199855

TIM9
Mitochondrial import inner membrane translocase subunit Tim9

1

1

High-throughput

0.691

High

241879

PRKN
E3 ubiquitin-protein ligase parkin

4

1

High-throughput

0.676

High

931245

AT12A
Potassium-transporting ATPase alpha chain 2

2

1

High-throughput

0.628

High

1199784

AGK
Acylglycerol kinase, mitochondrial

1

5

Small-scale

0.618

High

922731

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.602

High

1199810

AP3S1
AP-3 complex subunit sigma-1

2

0

High-throughput

0.602

High

1199839

RAB18
Ras-related protein Rab-18

2

0

High-throughput

0.602

High

1113272

CUL3
Cullin-3

2

0

High-throughput

0.585

High

1199849

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.584

High

830855

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

631260

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

1199811

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

1199815

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

170508

RAB7L
Ras-related protein Rab-7L1

1

2

High-throughput

0.536

High

172891

XPO1
Exportin-1

1

3

High-throughput

0.536

High

565630

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.536

High

675047

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.536

High

922257

LIMK1
LIM domain kinase 1

1

2

High-throughput

0.536

High

1014117

CBX1
Chromobox protein homolog 1

1

1

High-throughput

0.536

High

1023342

AT2C1
Calcium-transporting ATPase type 2C member 1

1

1

High-throughput

0.536

High

1199787

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.536

High

1199814

RSPRY
RING finger and SPRY domain-containing protein 1

1

2

High-throughput

0.536

High

1199842

PAK6
Serine/threonine-protein kinase PAK 6

1

1

High-throughput

0.536

High

1061

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.530

High

208050

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.513

High

634469

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

1123304

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1199786

GP107
Protein GPR107

1

0

High-throughput

0.513

High

1199795

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

1199797

DYM
Dymeclin

1

0

High-throughput

0.513

High

1199800

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

1199802

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

0

High-throughput

0.513

High

1199818

INT4
Integrator complex subunit 4

1

0

High-throughput

0.513

High

1199823

NEUR1
Sialidase-1

1

0

High-throughput

0.513

High

1199838

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

1199852

C2CD2
C2 domain-containing protein 2

1

0

High-throughput

0.513

High

1199856

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

High-throughput

0.513

High

289154

PRDM1
PR domain zinc finger protein 1

1

2

High-throughput

0.500

High

843626

HD
Huntingtin

1

0

High-throughput

0.493

High

132086

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

Small-scale

0.479

High

292143

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

320563

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

1

High-throughput

0.479

High

400936

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

402375

GBA1
Lysosomal acid glucosylceramidase

1

1

Small-scale

0.479

High

404109

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

412043

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

560868

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

Small-scale

0.479

High

573503

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

605706

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.479

High

761238

RYK
Tyrosine-protein kinase RYK

1

3

Small-scale

0.479

High

765587

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.479

High

766612

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

852671

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

1

Small-scale

0.479

High

1045361

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1067421

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1106933

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1121245

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

1123656

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.479

High

1137746

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1139442

S39AE
Metal cation symporter ZIP14

1

1

Small-scale

0.479

High

1199788

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1199791

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

1

Small-scale

0.479

High

1199793

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

1199794

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1199798

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

1199805

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

Small-scale

0.479

High

1199808

FBF1
Fas-binding factor 1

1

4

High-throughput

0.479

High

1199816

AURKB
Aurora kinase B

1

1

High-throughput

0.479

High

1199821

SFXN2
Sideroflexin-2

1

1

Small-scale

0.479

High

1199822

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1199833

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.479

High

1199834

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1199837

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1199841

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1199848

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

129147

MEN1
Menin

1

0

High-throughput

0.458

High

137735

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

184298

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

227583

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

229143

GTPB6
Putative GTP-binding protein 6

1

0

Small-scale

0.458

High

275033

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

293789

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319813

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

329839

SNX4
Sorting nexin-4

1

0

Small-scale

0.458

High

538609

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

Small-scale

0.458

High

560414

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

642911

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

731361

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

904803

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

970612

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1135889

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.458

High

1138285

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

Small-scale

0.458

High

1147767

DHC24
Delta(24)-sterol reductase

1

0

Small-scale

0.458

High

1162288

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

0

Small-scale

0.458

High

1197616

MIDN
Midnolin

1

0

High-throughput

0.458

High

1199789

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1199803

POC5
Centrosomal protein POC5

1

0

High-throughput

0.458

High

1199807

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1199817

TECT2
Tectonic-2

1

0

High-throughput

0.458

High

1199819

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1199820

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1199826

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1199829

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1199830

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

1199835

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1199836

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

1199843

ANLN
Anillin

1

0

High-throughput

0.458

High

1199844

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1199846

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1199847

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1199853

TIM22
Mitochondrial import inner membrane translocase subunit Tim22

1

0

Small-scale

0.458

High

1199827

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

422246

A4
Amyloid-beta precursor protein

1

1

Small-scale

0.445

High

943954

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

1040138

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

2

High-throughput

0.445

High

1199489

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

1199796

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.445

High

1199804

MFSD9
Major facilitator superfamily domain-containing protein 9

1

1

High-throughput

0.445

High

1199813

S2538
Mitochondrial glycine transporter

1

2

High-throughput

0.445

High

377594

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

406248

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

964998

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

1199845

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

1199851

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

211136

CTR4
Cationic amino acid transporter 4

1

0

High-throughput

0.426

High

529917

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

844932

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.426

High

1199785

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1199799

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.426

High

1199824

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

0

High-throughput

0.426

High

1199828

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.426

High

372205

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.407

High

1193259

SV2C
Synaptic vesicle glycoprotein 2C

1

2

High-throughput

0.407

High

1199840

S39A2
Zinc transporter ZIP2

1

1

High-throughput

0.407

High

1041665

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.279

Low

1160910

PRSS8
Prostasin

1

0

High-throughput

0.279

Low

1199850

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

194220

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

279383

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

1199790

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1199792

CNNM4
Metal transporter CNNM4

1

0

Small-scale

0.249

Low

1199801

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1199806

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1199809

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

Small-scale

0.249

Low

1199831

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1199832

CYTM1
Cysteine-rich and transmembrane domain-containing protein 1

1

0

Small-scale

0.249

Low

1199076

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

1199812

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025