Protein: MUS81
Crossover junction endonuclease MUS81 (EC 3.1.22.-) (MMS and UV-sensitive protein 81)

Gene: MUS81
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: Q04149

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000727 - double-strand break repair via break-induced replication
GO:0003677 - DNA binding
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

747180

MMS4
Crossover junction endonuclease MMS4

15

0

Small-scale

0.934

High

693154

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

3

1

Small-scale

0.664

High

699413

RAD54
DNA repair and recombination protein RAD54

3

2

Small-scale

0.661

High

756179

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

Small-scale

0.537

High

356698

H4
Histone H4

1

1

High-throughput

0.536

High

606133

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.536

High

978597

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.536

High

978596

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.529

High

424913

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

454925

CDC16
Anaphase-promoting complex subunit CDC16

1

0

High-throughput

0.513

High

597894

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

697852

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.513

High

715729

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.513

High

763184

FHP
Flavohemoprotein

1

0

High-throughput

0.513

High

766694

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.513

High

767340

ICP55
Intermediate cleaving peptidase 55

1

0

High-throughput

0.513

High

773008

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

777141

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

778851

NOP2
25S rRNA

1

0

High-throughput

0.513

High

797390

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.513

High

860729

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.513

High

862736

H1
Histone H1

1

0

High-throughput

0.513

High

978588

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.513

High

978590

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.513

High

523438

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.504

High

645750

FEN1
Flap endonuclease 1

1

1

Small-scale

0.501

High

772267

RFC4
Replication factor C subunit 4

1

1

Small-scale

0.501

High

772436

RFC2
Replication factor C subunit 2

1

1

Small-scale

0.501

High

485582

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

498588

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

583259

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.500

High

624719

CG22
G2/mitotic-specific cyclin-2

1

0

High-throughput

0.486

High

767826

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.486

High

419634

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.480

High

550574

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

978591

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

376922

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

605145

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

633541

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

767725

IMB4
Importin subunit beta-4

1

0

High-throughput

0.479

High

887668

ACT
Actin

1

0

High-throughput

0.479

High

477436

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

679763

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.479

High

978589

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.479

High

978592

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

440914

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.458

High

535774

ABF1
ARS-binding factor 1

1

0

High-throughput

0.458

High

546536

AMPD
AMP deaminase

1

0

High-throughput

0.458

High

548492

DPOD
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

689292

SP110
Spindle pole body component 110

1

0

High-throughput

0.458

High

713720

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.458

High

733232

SA190
SIT4-associating protein SAP190

1

0

High-throughput

0.458

High

755033

NADE
Glutamine-dependent NAD(+) synthetase

1

0

High-throughput

0.458

High

774466

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.458

High

778474

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.458

High

784861

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

797156

RIM15
Serine/threonine-protein kinase RIM15

1

0

High-throughput

0.458

High

969002

SKO1
CRE-binding bZIP protein SKO1

1

0

High-throughput

0.458

High

978594

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

0

High-throughput

0.458

High

978601

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.458

High

512604

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

769382

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

978586

GYL1
Probable GTPase-activating protein GYL1

1

1

High-throughput

0.437

High

978599

GYP5
GTPase-activating protein GYP5

1

1

High-throughput

0.437

High

492330

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

866832

EFM6
Protein-lysine N-methyltransferase EFM6

2

0

High-throughput

0.307

High

811143

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.282

High

333990

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.279

Low

343856

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

546784

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.279

Low

691417

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.279

Low

733925

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

757333

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.279

Low

791272

KRI1
Protein KRI1

1

0

High-throughput

0.279

Low

866043

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.279

Low

978593

NOP12
Nucleolar protein 12

1

0

High-throughput

0.279

Low

764126

RV167
Reduced viability upon starvation protein 167

1

0

Small-scale

0.265

Low

343683

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

368378

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

381716

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

397615

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

604467

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

619635

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

772733

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

785201

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

811454

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.261

Low

867520

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.261

Low

482935

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

535273

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.249

Low

563985

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.249

Low

595068

NUP1
Nucleoporin NUP1

1

0

High-throughput

0.249

Low

732181

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.249

Low

750053

TPS3
Trehalose synthase complex regulatory subunit TPS3

1

0

High-throughput

0.249

Low

752271

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.249

Low

766406

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

771786

PEP8
Carboxypeptidase Y-deficient protein 8

1

0

High-throughput

0.249

Low

866731

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.249

Low

866876

HDA1
Histone deacetylase HDA1

1

0

High-throughput

0.249

Low

978587

GRH1
GRASP65 homolog protein 1

1

0

High-throughput

0.249

Low

978595

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.249

Low

978598

BUG1
Binder of USO1 and GRH1 protein 1

1

0

High-throughput

0.249

Low

978600

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.249

Low

978602

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.249

Low

629771

STE50
Protein STE50

1

0

High-throughput

0.238

Low

973025

YP108
Uncharacterized protein YPL108W

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024