Protein: RSPRY
RING finger and SPRY domain-containing protein 1

Gene: RSPRY, RSPRY1
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q96DX4

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding
GO:0051603 - proteolysis involved in protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982278

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

7

High-throughput

0.800

High

957159

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

7

High-throughput

0.698

High

333700

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

3

1

High-throughput

0.667

High

1251993

TM11A
Transmembrane protease serine 11A

3

1

High-throughput

0.667

High

174265

ARHGA
Rho guanine nucleotide exchange factor 10

3

7

High-throughput

0.656

High

1105157

U119A
Protein unc-119 homolog A

4

1

High-throughput

0.630

High

144107

WNT7A
Protein Wnt-7a

2

3

High-throughput

0.628

High

366587

CFAB
Complement factor B

2

4

High-throughput

0.628

High

424539

PAI2
Plasminogen activator inhibitor 2

2

5

High-throughput

0.628

High

451235

NFL
Neurofilament light polypeptide

2

6

High-throughput

0.628

High

474887

VIME
Vimentin

2

6

High-throughput

0.628

High

699570

IL1R2
Interleukin-1 receptor type 2

2

5

High-throughput

0.628

High

876625

NEST
Nestin

2

17

High-throughput

0.628

High

1248782

LYZL1
Lysozyme-like protein 1

2

1

High-throughput

0.628

High

1278870

LYZL2
Lysozyme-like protein 2

2

1

High-throughput

0.628

High

1329337

ATL1
ADAMTS-like protein 1

2

9

High-throughput

0.628

High

242549

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

1255008

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1308249

CCNJL
Cyclin-J-like protein

2

2

High-throughput

0.611

High

643973

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

1

High-throughput

0.609

High

288194

CLC3A
C-type lectin domain family 3 member A

3

1

High-throughput

0.604

High

628590

ISK2
Serine protease inhibitor Kazal-type 2

2

0

High-throughput

0.602

High

1388010

MACIR
Macrophage immunometabolism regulator

2

0

High-throughput

0.602

High

1382693

EMID1
EMI domain-containing protein 1

2

4

High-throughput

0.601

High

570706

EDN3
Endothelin-3

2

0

High-throughput

0.576

High

225453

ITM2A
Integral membrane protein 2A

2

1

High-throughput

0.574

High

335666

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

1

High-throughput

0.574

High

451430

NFM
Neurofilament medium polypeptide

2

12

High-throughput

0.574

High

732842

GLPK
Glycerol kinase

2

1

High-throughput

0.574

High

1126278

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

2

3

High-throughput

0.574

High

1157244

AINX
Alpha-internexin

2

7

High-throughput

0.574

High

1177059

INF2
Inverted formin-2

2

4

High-throughput

0.574

High

1355879

XAGE3
X antigen family member 3

2

1

High-throughput

0.574

High

1388017

RM17
Large ribosomal subunit protein bL17m

2

1

High-throughput

0.574

High

570547

GFAP
Glial fibrillary acidic protein

1

6

High-throughput

0.536

High

1025496

CDK5
Cyclin-dependent kinase 5

1

5

High-throughput

0.536

High

1142250

CD5R1
Cyclin-dependent kinase 5 activator 1

1

1

High-throughput

0.536

High

1199814

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.536

High

1388023

TM11E
Transmembrane protease serine 11E

1

1

High-throughput

0.536

High

1388027

CBPQ
Carboxypeptidase Q

1

2

High-throughput

0.536

High

641317

SIAL
Integrin-binding sialoprotein

1

0

High-throughput

0.513

High

1233175

ISM2
Isthmin-2

1

0

High-throughput

0.513

High

1388012

PRIPO
DNA-directed primase/polymerase protein

1

0

High-throughput

0.513

High

1388022

PRND
Prion-like protein doppel

1

0

High-throughput

0.513

High

67433

GOG8A
Golgin subfamily A member 8A

1

14

High-throughput

0.489

High

640983

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.489

High

688709

NKG2D
NKG2-D type II integral membrane protein

1

1

High-throughput

0.489

High

926822

VMAT1
Chromaffin granule amine transporter

1

2

High-throughput

0.489

High

1258735

5HT3D
5-hydroxytryptamine receptor 3D

1

1

High-throughput

0.489

High

1388011

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

High-throughput

0.489

High

1388014

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.489

High

1388016

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.489

High

1388021

IL17B
Interleukin-17B

1

2

High-throughput

0.489

High

1388024

SC5A6
Sodium-dependent multivitamin transporter

1

2

High-throughput

0.489

High

1388026

PCDG9
Protocadherin gamma-A9

1

5

High-throughput

0.489

High

248035

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

914324

EFNA4
Ephrin-A4

1

1

High-throughput

0.479

High

1004953

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1045626

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1113954

CUL3
Cullin-3

1

19

High-throughput

0.479

High

1140679

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1278269

NPHP3
Nephrocystin-3

1

6

High-throughput

0.479

High

1388013

NODAL
Nodal homolog

1

6

High-throughput

0.470

High

303341

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

3

High-throughput

0.437

High

332692

LYPD3
Ly6/PLAUR domain-containing protein 3

1

0

High-throughput

0.426

High

1206059

DYLT4
Dynein light chain Tctex-type 4

1

0

High-throughput

0.426

High

1271324

CHST9
Carbohydrate sulfotransferase 9

1

0

High-throughput

0.426

High

1388019

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

0

High-throughput

0.426

High

96808

E9PB39
Rho guanine nucleotide exchange factor 10

1

8

High-throughput

0.407

High

1239533

ZNT6
Zinc transporter 6

1

1

High-throughput

0.407

High

1388015

S28A3
Solute carrier family 28 member 3

1

1

High-throughput

0.407

High

1388018

CCG4
Voltage-dependent calcium channel gamma-4 subunit

3

0

High-throughput

0.339

High

829914

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.328

High

1279271

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.328

High

854570

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.279

Low

1092800

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1388020

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

1308185

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

569266

YJU2B
Probable splicing factor YJU2B

1

0

High-throughput

0.232

Low

1388025

ZDHC9
Palmitoyltransferase ZDHHC9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025