Protein: DEF5
Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]

Gene: DEF5, DEFA5
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q01523

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005796 - Golgi lumen
GO:0019731 - antibacterial humoral response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

323983

CSTN1
Calsyntenin-1

3

2

High-throughput

0.662

High

1030783

T132A
Transmembrane protein 132A

3

1

High-throughput

0.662

High

1030806

HTRA1
Serine protease HTRA1

3

1

High-throughput

0.662

High

1030793

WAPL
Wings apart-like protein homolog

3

0

High-throughput

0.634

High

249039

NRP2
Neuropilin-2

2

3

High-throughput

0.628

High

1030774

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.628

High

1030779

LTBP1
Latent-transforming growth factor beta-binding protein 1

2

4

High-throughput

0.628

High

1030784

MICA
MHC class I polypeptide-related sequence A

2

1

High-throughput

0.628

High

1030786

METRL
Meteorin-like protein

2

1

High-throughput

0.628

High

1030799

C1QL4
Complement C1q-like protein 4

2

2

High-throughput

0.628

High

1030800

CILP2
Cartilage intermediate layer protein 2

2

1

High-throughput

0.628

High

1030801

SULF2
Extracellular sulfatase Sulf-2

2

4

High-throughput

0.628

High

1030810

EMIL2
EMILIN-2

2

3

High-throughput

0.628

High

1030825

LOXL2
Lysyl oxidase homolog 2

2

1

High-throughput

0.628

High

1030773

DEF5
Defensin alpha 5

1

3

Small-scale

0.618

High

175358

PLXB2
Plexin-B2

3

5

High-throughput

0.604

High

1030809

MCMBP
Mini-chromosome maintenance complex-binding protein

3

1

High-throughput

0.604

High

1030818

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

3

1

High-throughput

0.604

High

1030821

PLXA1
Plexin-A1

3

5

High-throughput

0.604

High

1030811

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.602

High

133182

QSOX1
Sulfhydryl oxidase 1

2

0

High-throughput

0.602

High

322136

GLCE
D-glucuronyl C5-epimerase

2

0

High-throughput

0.602

High

1030781

RHG19
Rho GTPase-activating protein 19

2

0

High-throughput

0.602

High

1030782

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

2

0

High-throughput

0.602

High

1030817

KTU
Protein kintoun

2

0

High-throughput

0.602

High

239487

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

2

1

High-throughput

0.574

High

269663

PLXA2
Plexin-A2

2

5

High-throughput

0.574

High

299871

C1QRF
C1q-related factor

2

2

High-throughput

0.574

High

891464

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.574

High

1030785

FREM2
FRAS1-related extracellular matrix protein 2

2

3

High-throughput

0.574

High

1030795

KAISO
Transcriptional regulator Kaiso

2

1

High-throughput

0.574

High

1030797

FRAS1
Extracellular matrix organizing protein FRAS1

2

4

High-throughput

0.574

High

1030805

IP6K1
Inositol hexakisphosphate kinase 1

2

1

High-throughput

0.574

High

1030827

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

1

High-throughput

0.574

High

572685

NID1
Nidogen-1

1

2

High-throughput

0.536

High

774760

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

1013364

HTRA3
Serine protease HTRA3

1

1

High-throughput

0.536

High

1030790

CD109
CD109 antigen

1

1

High-throughput

0.536

High

1030808

PADC1
Protease-associated domain-containing protein 1

1

2

High-throughput

0.536

High

1030822

METRN
Meteorin

1

1

High-throughput

0.536

High

377853

GAST
Gastrin [Cleaved into: Gastrin-71

1

0

High-throughput

0.513

High

891120

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.489

High

1030788

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

551781

CO6A1

1

3

High-throughput

0.445

High

551853

CO6A2

1

3

High-throughput

0.445

High

562714

BMP1
Bone morphogenetic protein 1

1

4

High-throughput

0.445

High

1030776

LAMB3
Laminin subunit beta-3

1

4

High-throughput

0.445

High

1030777

LAMC2
Laminin subunit gamma-2

1

6

High-throughput

0.445

High

1030780

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

5

High-throughput

0.445

High

1030823

MKLN1
Muskelin

1

1

High-throughput

0.445

High

893827

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

133737

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.426

High

1030778

FAT1
Protocadherin Fat 1

1

1

High-throughput

0.407

High

1030804

TM131
Transmembrane protein 131

1

1

High-throughput

0.407

High

765403

BMI1
Polycomb complex protein BMI-1

3

0

Small-scale

0.355

High

547133

PYC
Pyruvate carboxylase, mitochondrial

3

0

High-throughput

0.345

High

1030791

TMTC3
Protein O-mannosyl-transferase TMTC3

3

0

High-throughput

0.345

High

71721

NUD19
Acyl-coenzyme A diphosphatase NUDT19

2

0

High-throughput

0.328

High

244052

SUSD5
Sushi domain-containing protein 5

2

0

High-throughput

0.328

High

294853

BCAR3
Breast cancer anti-estrogen resistance protein 3

2

0

High-throughput

0.328

High

658119

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.328

High

699698

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.328

High

838986

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

0

High-throughput

0.328

High

882635

EFTU
Elongation factor Tu, mitochondrial

2

0

High-throughput

0.328

High

1013741

RL24
Large ribosomal subunit protein eL24

2

0

High-throughput

0.328

High

1030775

HSP7E
Heat shock 70 kDa protein 14

2

0

High-throughput

0.328

High

1030787

VIR
Protein virilizer homolog

2

0

High-throughput

0.328

High

1030789

KLD10
Kelch domain-containing protein 10

2

0

High-throughput

0.328

High

1030796

SHLD2
Shieldin complex subunit 2

2

0

High-throughput

0.328

High

1030802

RDH13
Retinol dehydrogenase 13

2

0

High-throughput

0.328

High

1030803

XAGE3
X antigen family member 3

2

0

High-throughput

0.328

High

1030814

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.328

High

1030815

PCDBG
Protocadherin beta-16

2

0

High-throughput

0.328

High

1030816

ZN277
Zinc finger protein 277

2

0

High-throughput

0.328

High

1030820

EPHA6
Ephrin type-A receptor 6

2

0

High-throughput

0.328

High

1030824

C170B
Centrosomal protein of 170 kDa protein B

2

0

High-throughput

0.328

High

1030826

VATD
V-type proton ATPase subunit D

2

0

High-throughput

0.313

High

1030798

DTX1
E3 ubiquitin-protein ligase DTX1

1

0

High-throughput

0.282

High

1030794

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.279

Low

1030812

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.279

Low

338819

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.232

Low

1030792

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.232

Low

1030807

C102A
Coiled-coil domain-containing protein 102A

1

0

High-throughput

0.232

Low

1030813

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.232

Low

1030819

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025