Protein: EI2BA
Translation initiation factor eIF2B subunit alpha (GCD complex subunit GCN3) (Guanine nucleotide exchange factor subunit GCN3) (Translational activator GCN3) (eIF2B GDP-GTP exchange factor subunit alpha)

Gene: EI2BA, GCN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P14741

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005851 - eukaryotic translation initiation factor 2B complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539962

EI2BB
Translation initiation factor eIF2B subunit beta

12

13

Small-scale

0.981

High

539961

EI2BE
Translation initiation factor eIF2B subunit epsilon

10

14

Small-scale

0.973

High

521165

EI2BD
Translation initiation factor eIF2B subunit delta

8

14

Small-scale

0.971

High

539946

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

4

4

Small-scale

0.892

High

539936

EI2BA
Translation initiation factor eIF2B subunit alpha

3

13

High-throughput

0.838

High

446962

EI2BG
Translation initiation factor eIF2B subunit gamma

10

14

Small-scale

0.757

High

447152

IF2B
Eukaryotic translation initiation factor 2 subunit beta

5

7

Small-scale

0.714

High

539960

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

4

7

High-throughput

0.697

High

539947

CLH
Clathrin heavy chain

3

0

High-throughput

0.622

High

539982

TCPD
T-complex protein 1 subunit delta

3

2

High-throughput

0.599

High

510117

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.584

High

406736

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.571

High

477851

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.552

High

539955

BMH1
Protein BMH1

2

4

High-throughput

0.543

High

540010

RUVB1
RuvB-like protein 1

2

2

High-throughput

0.543

High

540003

IST1
Vacuolar protein sorting-associated protein IST1

2

2

High-throughput

0.537

High

343264

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

4

High-throughput

0.536

High

539939

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

2

High-throughput

0.536

High

539954

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.536

High

539991

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.536

High

360721

TBB
Tubulin beta chain

2

2

High-throughput

0.533

High

539942

VATB
V-type proton ATPase subunit B

2

2

High-throughput

0.533

High

539976

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

2

Small-scale

0.521

High

539994

MPG1
Mannose-1-phosphate guanyltransferase

1

10

High-throughput

0.514

High

539993

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

540000

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

334422

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

4

High-throughput

0.500

High

334879

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

4

High-throughput

0.500

High

342637

ENO1
Enolase 1

1

2

High-throughput

0.500

High

378267

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.500

High

381414

GAL1
Galactokinase

1

1

High-throughput

0.500

High

381677

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.500

High

393513

PMA1
Plasma membrane ATPase 1

1

1

High-throughput

0.500

High

410882

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

449884

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.500

High

539937

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.500

High

539945

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

539952

URA7
CTP synthase 1

1

1

High-throughput

0.500

High

539959

EF2
Elongation factor 2

1

2

High-throughput

0.500

High

539985

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.500

High

539958

GLPK
Glycerol kinase

1

0

High-throughput

0.493

High

343173

TRP
Tryptophan synthase

1

1

High-throughput

0.489

High

539940

BGL2
Glucan 1,3-beta-glucosidase

1

1

High-throughput

0.489

High

539956

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.489

High

539957

XPO1
Exportin-1

1

9

High-throughput

0.489

High

539966

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

539983

FHL1
Pre-rRNA-processing protein FHL1

1

3

High-throughput

0.489

High

539989

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

2

High-throughput

0.489

High

539996

GUF1
Translation factor GUF1, mitochondrial

1

3

High-throughput

0.489

High

424983

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.479

High

520897

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

407688

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

408258

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

5

High-throughput

0.479

High

539938

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

539949

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

539971

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

539979

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

539984

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

540001

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

540004

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

540007

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

540013

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

540014

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

539998

LSM1
Sm-like protein LSm1

1

1

High-throughput

0.464

High

539967

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

540006

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

Small-scale

0.458

High

440848

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.457

High

454155

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.457

High

454542

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.457

High

539941

HSP26
Heat shock protein 26

1

5

High-throughput

0.457

High

539943

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.457

High

539964

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.457

High

539968

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.457

High

539980

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.457

High

540005

ACT
Actin

1

2

High-throughput

0.457

High

540015

HSP42
Heat shock protein 42

1

5

High-throughput

0.457

High

365701

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.445

High

367681

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

424318

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

490201

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

539965

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

539988

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

539992

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.445

High

539950

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

539953

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

539970

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

539975

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

540008

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

339991

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

350759

RAS1
Ras-like protein 1

1

1

High-throughput

0.407

High

539999

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.407

High

539978

BIT2
Probable target of rapamycin complex 2 subunit BIT2

2

0

High-throughput

0.323

High

423981

CBP6
Cytochrome B pre-mRNA-processing protein 6

1

0

High-throughput

0.279

Low

539944

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.279

Low

539969

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.279

Low

539972

PET10
Protein PET10

1

0

High-throughput

0.279

Low

539977

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.279

Low

539981

HXT7
High-affinity hexose transporter HXT7

1

0

High-throughput

0.279

Low

539986

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.279

Low

540011

YHM2
Citrate/oxoglutarate carrier protein

1

0

High-throughput

0.279

Low

539973

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.269

Low

539974

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.269

Low

539951

IPYR2
Inorganic pyrophosphatase, mitochondrial

1

0

High-throughput

0.265

Low

539963

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.265

Low

539987

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

High-throughput

0.265

Low

540002

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.265

Low

540009

TMA23
Protein TMA23

1

0

High-throughput

0.265

Low

539948

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

539990

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

539995

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

539516

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low

539997

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

540012

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024