Protein: KAT2B
Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)

Gene: KAT2B
Organism: Homo sapiens
Interactions: 240
UniProt ID: Q92831

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000124 - SAGA complex
GO:0000432 - positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000776 - kinetochore
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1271479

KAT2B
Histone acetyltransferase KAT2B

10

17

Small-scale

0.978

High

998943

EP300
Histone acetyltransferase p300

7

20

Small-scale

0.964

High

266399

TAD2A
Transcriptional adapter 2-alpha

6

20

Small-scale

0.940

High

1270757

CBP
CREB-binding protein

5

20

Small-scale

0.930

High

267784

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

5

20

Small-scale

0.912

High

903409

WDR5
WD repeat-containing protein 5

4

20

Small-scale

0.895

High

1198566

TAD2B
Transcriptional adapter 2-beta

3

20

High-throughput

0.827

High

1271500

CSR2B
Cysteine-rich protein 2-binding protein

2

6

High-throughput

0.789

High

387227

P53
Cellular tumor antigen p53

15

15

Small-scale

0.762

High

917689

H4
Histone H4

14

19

Small-scale

0.760

High

935070

H31
Histone H3.1

12

20

Small-scale

0.759

High

772088

VHL
von Hippel-Lindau disease tumor suppressor

2

3

Small-scale

0.754

High

1223166

ZZZ3
ZZ-type zinc finger-containing protein 3

2

3

High-throughput

0.754

High

267676

TADA3
Transcriptional adapter 3

10

6

Small-scale

0.753

High

266495

SUPT3
Transcription initiation protein SPT3 homolog

7

5

Small-scale

0.739

High

1271434

KAT2A
Histone acetyltransferase KAT2A

2

18

Small-scale

0.737

High

1062107

AT7L3
Ataxin-7-like protein 3

6

4

High-throughput

0.733

High

1271484

SGF29
SAGA-associated factor 29

6

3

High-throughput

0.733

High

1271524

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

6

11

Small-scale

0.733

High

963659

E2F1
Transcription factor E2F1

6

11

Small-scale

0.724

High

1021631

TAF10
Transcription initiation factor TFIID subunit 10

6

10

Small-scale

0.724

High

1271487

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

20

Small-scale

0.724

High

962898

MDM2
E3 ubiquitin-protein ligase Mdm2

5

1

Small-scale

0.723

High

1271482

TADA1
Transcriptional adapter 1

5

3

High-throughput

0.714

High

1271504

MBIP1
MAP3K12-binding inhibitory protein 1

5

4

Small-scale

0.714

High

1271519

TRRAP
Transformation/transcription domain-associated protein

5

11

Small-scale

0.706

High

546021

MYOD1
Myoblast determination protein 1

5

13

Small-scale

0.702

High

1085624

HIF1A
Hypoxia-inducible factor 1-alpha

4

10

Small-scale

0.696

High

1082068

TAF12
Transcription initiation factor TFIID subunit 12

4

7

Small-scale

0.694

High

1138818

MYSM1
Deubiquitinase MYSM1

1

20

Small-scale

0.690

High

1243302

SP20H
Transcription factor SPT20 homolog

4

4

High-throughput

0.686

High

950237

SMAD3
Mothers against decapentaplegic homolog 3

4

13

Small-scale

0.680

High

1078608

SMAD2
Mothers against decapentaplegic homolog 2

4

13

Small-scale

0.680

High

1078531

NCOA1
Nuclear receptor coactivator 1

3

12

Small-scale

0.672

High

796240

MAGAA
Melanoma-associated antigen 10

3

7

High-throughput

0.667

High

966180

NC2B
Protein Dr1

3

9

Small-scale

0.656

High

1083686

TAF9
Transcription initiation factor TFIID subunit 9

3

11

Small-scale

0.656

High

1271483

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

15

Small-scale

0.655

High

391825

H2A1B
Histone H2A type 1-B/E

3

20

Small-scale

0.655

High

707702

H2B1B
Histone H2B type 1-B

3

20

Small-scale

0.655

High

702501

C2TA
MHC class II transactivator

2

4

Small-scale

0.653

High

1032542

CTBP1
C-terminal-binding protein 1

3

8

Small-scale

0.651

High

236963

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

2

7

Small-scale

0.641

High

436738

GLI1
Zinc finger protein GLI1

3

11

Small-scale

0.640

High

488002

RARA
Retinoic acid receptor alpha

3

20

Small-scale

0.640

High

1271511

YETS2
YEATS domain-containing protein 2

3

15

Small-scale

0.640

High

536543

IRF2
Interferon regulatory factor 2

2

8

Small-scale

0.639

High

966987

SATB1
DNA-binding protein SATB1

2

2

Small-scale

0.639

High

1271518

KLF13
Krueppel-like factor 13

2

20

Small-scale

0.639

High

1076851

TWST1
Twist-related protein 1

2

11

Small-scale

0.639

High

847865

BRCA2
Breast cancer type 2 susceptibility protein

3

0

Small-scale

0.636

High

414346

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.634

High

175902

P73
Tumor protein p73

2

15

Small-scale

0.631

High

551562

TFE2
Transcription factor E2-alpha

2

4

Small-scale

0.629

High

1271497

IKZF5
Zinc finger protein Pegasus

2

13

High-throughput

0.628

High

622502

CCND1
G1/S-specific cyclin-D1

2

7

Small-scale

0.624

High

624979

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

8

Small-scale

0.624

High

974633

MECOM
Histone-lysine N-methyltransferase MECOM

2

13

Small-scale

0.624

High

435151

SP1
Transcription factor Sp1

2

20

Small-scale

0.620

High

846838

SMCA2
Probable global transcription activator SNF2L2

1

20

Small-scale

0.618

High

891944

ACTB
Actin, cytoplasmic 1

1

5

Small-scale

0.618

High

1271512

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.618

High

1271517

WDR37
WD repeat-containing protein 37

1

20

High-throughput

0.618

High

487640

ANDR
Androgen receptor

2

20

Small-scale

0.611

High

1073091

SF3B3
Splicing factor 3B subunit 3

2

10

High-throughput

0.611

High

1220752

SIR2
NAD-dependent protein deacetylase sirtuin-2

2

15

Small-scale

0.611

High

971293

H11
Histone H1.1

2

10

Small-scale

0.602

High

1086257

H31T
Histone H3.1t

2

20

Small-scale

0.602

High

1174616

H32
Histone H3.2

2

20

Small-scale

0.602

High

1271496

P63
Tumor protein 63

2

15

Small-scale

0.602

High

607832

USF1
Upstream stimulatory factor 1

1

20

Small-scale

0.597

High

347493

MYC
Myc proto-oncogene protein

2

20

Small-scale

0.595

High

414519

PRGR
Progesterone receptor

2

20

Small-scale

0.595

High

501076

IRF1
Interferon regulatory factor 1

2

8

Small-scale

0.595

High

632839

TYY1
Transcriptional repressor protein YY1

2

18

Small-scale

0.595

High

919805

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

8

Small-scale

0.595

High

1271525

NCOA3
Nuclear receptor coactivator 3

2

12

Small-scale

0.594

High

1271485

SAT2
Thialysine N-epsilon-acetyltransferase

1

0

High-throughput

0.589

High

297924

ST65G
STAGA complex 65 subunit gamma

2

1

High-throughput

0.584

High

316953

KLF8
Krueppel-like factor 8

2

20

Small-scale

0.584

High

826325

CDK8
Cyclin-dependent kinase 8

2

13

Small-scale

0.584

High

881248

CTBP2
C-terminal-binding protein 2

2

8

Small-scale

0.584

High

952516

H33
Histone H3.3

2

20

Small-scale

0.584

High

965415

FLI1
Friend leukemia integration 1 transcription factor

2

20

Small-scale

0.584

High

1271501

TAF9B
Transcription initiation factor TFIID subunit 9B

2

11

High-throughput

0.584

High

1271502

ENY2
Transcription and mRNA export factor ENY2

2

5

High-throughput

0.584

High

1271514

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

14

High-throughput

0.584

High

567869

HXB9
Homeobox protein Hox-B9

1

3

Small-scale

0.578

High

568221

TAL1
T-cell acute lymphocytic leukemia protein 1

1

7

Small-scale

0.578

High

590211

CCNA2
Cyclin-A2

1

4

Small-scale

0.578

High

625534

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.578

High

651853

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.578

High

681962

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.578

High

717255

CTNB1
Catenin beta-1

1

15

Small-scale

0.578

High

804143

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.578

High

840441

ETV1
ETS translocation variant 1

1

20

Small-scale

0.578

High

1080191

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.578

High

1082605

MK14
Mitogen-activated protein kinase 14

1

6

Small-scale

0.578

High

1168919

LN28B
Protein lin-28 homolog B

1

1

Small-scale

0.578

High

1271503

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

15

Small-scale

0.578

High

1271522

KLF2
Krueppel-like factor 2

1

20

Small-scale

0.578

High

177347

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.561

High

510031

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.561

High

595947

HNF1A
Hepatocyte nuclear factor 1-alpha

1

9

Small-scale

0.561

High

616725

KS6B1
Ribosomal protein S6 kinase beta-1

1

5

Small-scale

0.561

High

857495

HMGA2
High mobility group protein HMGI-C

1

2

Small-scale

0.561

High

962258

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

9

Small-scale

0.561

High

1048980

SRTD2
SERTA domain-containing protein 2

1

1

Small-scale

0.561

High

1186150

PTF1A
Pancreas transcription factor 1 subunit alpha

1

10

Small-scale

0.561

High

1271494

CDCA4
Cell division cycle-associated protein 4

1

3

Small-scale

0.561

High

1271506

KS6B2
Ribosomal protein S6 kinase beta-2

1

5

Small-scale

0.561

High

1271507

SRTD1
SERTA domain-containing protein 1

1

1

Small-scale

0.561

High

1271508

KLF15
Krueppel-like factor 15

1

20

Small-scale

0.561

High

1199949

NFE4
Transcription factor NF-E4

1

0

Small-scale

0.554

High

986954

SUH
Recombining binding protein suppressor of hairless

1

3

Small-scale

0.552

High

617766

NFYA
Nuclear transcription factor Y subunit alpha

2

0

Small-scale

0.547

High

868280

ATX3
Ataxin-3

1

0

Small-scale

0.537

High

569929

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.536

High

1077053

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

Small-scale

0.536

High

173984

ATX7
Ataxin-7

1

11

High-throughput

0.536

High

555570

H2AX
Histone H2AX

1

20

Small-scale

0.536

High

934363

CSK21
Casein kinase II subunit alpha

1

14

High-throughput

0.536

High

1271493

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.536

High

1271486

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

10

Small-scale

0.534

High

1134034

AT7L2
Ataxin-7-like protein 2

2

8

High-throughput

0.533

High

1024872

KLF10
Krueppel-like factor 10

1

20

Small-scale

0.527

High

855701

KIF11
Kinesin-like protein KIF11

1

5

Small-scale

0.515

High

165774

N4BP3
NEDD4-binding protein 3

1

6

Small-scale

0.512

High

946010

DHI2
11-beta-hydroxysteroid dehydrogenase type 2

1

1

Small-scale

0.512

High

126157

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

9

Small-scale

0.501

High

181550

CLOCK
Circadian locomoter output cycles protein kaput

1

12

Small-scale

0.501

High

231137

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

Small-scale

0.501

High

236815

CCNT1
Cyclin-T1

1

15

Small-scale

0.501

High

318002

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

8

Small-scale

0.501

High

398922

HMGN2
Non-histone chromosomal protein HMG-17

1

6

Small-scale

0.501

High

455722

PARP1
Poly [ADP-ribose] polymerase 1

1

17

Small-scale

0.501

High

523914

XRCC6
X-ray repair cross-complementing protein 6

1

9

Small-scale

0.501

High

559200

H15
Histone H1.5

1

13

Small-scale

0.501

High

564984

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

Small-scale

0.501

High

579276

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

1

Small-scale

0.501

High

611480

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.501

High

641253

DNMT1
DNA

1

16

Small-scale

0.501

High

727409

DEK
Protein DEK

1

3

Small-scale

0.501

High

742445

SYUA
Alpha-synuclein

1

3

High-throughput

0.501

High

764669

CUX1
Homeobox protein cut-like 1

1

16

Small-scale

0.501

High

849391

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

8

Small-scale

0.501

High

854813

GDIR1
Rho GDP-dissociation inhibitor 1

1

2

Small-scale

0.501

High

895863

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

8

Small-scale

0.501

High

929342

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

Small-scale

0.501

High

1071739

TTF1
Transcription termination factor 1

1

6

Small-scale

0.501

High

1083921

NFE2
Transcription factor NF-E2 45 kDa subunit

1

15

Small-scale

0.501

High

1087073

H2A2C
Histone H2A type 2-C

1

20

Small-scale

0.501

High

1087312

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.501

High

1271481

IRF7
Interferon regulatory factor 7

1

8

Small-scale

0.501

High

1271490

NPAS2
Neuronal PAS domain-containing protein 2

1

11

Small-scale

0.501

High

1271505

HNF6
Hepatocyte nuclear factor 6

1

11

Small-scale

0.501

High

1271513

PLAL1
Zinc finger protein PLAGL1

1

13

Small-scale

0.501

High

1191503

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

521592

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.481

High

725683

ACTN2
Alpha-actinin-2

1

4

High-throughput

0.481

High

914263

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.481

High

946742

TMF1
TATA element modulatory factor

1

4

High-throughput

0.481

High

1025264

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

1049103

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.481

High

1240900

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.481

High

1271492

CP250
Centrosome-associated protein CEP250

1

10

High-throughput

0.481

High

673508

MPIP2
M-phase inducer phosphatase 2

1

0

Small-scale

0.480

High

791825

HD
Huntingtin

1

0

Small-scale

0.480

High

1045308

NCOA4
Nuclear receptor coactivator 4

1

0

Small-scale

0.480

High

1271495

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.480

High

64215

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

11

High-throughput

0.479

High

117786

MYO1C
Unconventional myosin-Ic

1

2

Small-scale

0.479

High

166179

ZBTB5
Zinc finger and BTB domain-containing protein 5

1

14

Small-scale

0.479

High

167379

SMAD7
Mothers against decapentaplegic homolog 7

1

13

Small-scale

0.479

High

171425

SMAD9
Mothers against decapentaplegic homolog 9

1

13

Small-scale

0.479

High

199132

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.479

High

311827

TACC2
Transforming acidic coiled-coil-containing protein 2

1

12

Small-scale

0.479

High

317141

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

8

Small-scale

0.479

High

331319

CHK2
Serine/threonine-protein kinase Chk2

1

3

Small-scale

0.479

High

345508

FOS
Protein c-Fos

1

12

Small-scale

0.479

High

379678

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

402306

JUN
Transcription factor Jun

1

19

Small-scale

0.479

High

426533

KLK3
Prostate-specific antigen

1

2

Small-scale

0.479

High

437648

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

505271

EGR2
E3 SUMO-protein ligase EGR2

1

12

High-throughput

0.479

High

542054

ETS1
Protein C-ets-1

1

20

Small-scale

0.479

High

556934

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.479

High

571821

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

627439

NFYB
Nuclear transcription factor Y subunit beta

1

9

Small-scale

0.479

High

678801

HXA10
Homeobox protein Hox-A10

1

3

Small-scale

0.479

High

692169

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

714339

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

740568

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

758300

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

Small-scale

0.479

High

776771

STAT3
Signal transducer and activator of transcription 3

1

8

Small-scale

0.479

High

782612

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

790836

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

14

Small-scale

0.479

High

822656

LHX1
LIM/homeobox protein Lhx1

1

12

High-throughput

0.479

High

837056

MRE11
Double-strand break repair protein MRE11

1

3

Small-scale

0.479

High

862447

ACLY
ATP-citrate synthase

1

1

Small-scale

0.479

High

884215

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

890781

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.479

High

971672

PAX5
Paired box protein Pax-5

1

5

Small-scale

0.479

High

976490

ERCC6
DNA excision repair protein ERCC-6

1

20

Small-scale

0.479

High

992181

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.479

High

1017198

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

6

Small-scale

0.479

High

1037080

MED21
Mediator of RNA polymerase II transcription subunit 21

1

3

Small-scale

0.479

High

1039461

IRF5
Interferon regulatory factor 5

1

8

Small-scale

0.479

High

1047425

RUNX2
Runt-related transcription factor 2

1

5

Small-scale

0.479

High

1047524

NFYC
Nuclear transcription factor Y subunit gamma

1

5

Small-scale

0.479

High

1048158

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

9

Small-scale

0.479

High

1059591

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.479

High

1158986

EDC4
Enhancer of mRNA-decapping protein 4

1

14

High-throughput

0.479

High

1174026

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

14

High-throughput

0.479

High

1204063

CARM1
Histone-arginine methyltransferase CARM1

1

4

Small-scale

0.479

High

1205791

P66A
Transcriptional repressor p66-alpha

1

9

Small-scale

0.479

High

1230496

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.479

High

1246066

MAFA
Transcription factor MafA

1

9

Small-scale

0.479

High

1254871

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1263948

P66B
Transcriptional repressor p66-beta

1

9

Small-scale

0.479

High

1271147

RBP56
TATA-binding protein-associated factor 2N

1

8

Small-scale

0.479

High

1271480

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.479

High

1271488

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1271489

KLF6
Krueppel-like factor 6

1

20

High-throughput

0.479

High

1271491

NKX31
Homeobox protein Nkx-3.1

1

4

Small-scale

0.479

High

1271509

ING1
Inhibitor of growth protein 1

1

19

Small-scale

0.479

High

1271510

MED23
Mediator of RNA polymerase II transcription subunit 23

1

4

High-throughput

0.479

High

1271516

CTND2
Catenin delta-2

1

16

Small-scale

0.479

High

1271520

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

1271521

MAFB
Transcription factor MafB

1

14

Small-scale

0.479

High

1271523

TACC3
Transforming acidic coiled-coil-containing protein 3

1

7

Small-scale

0.479

High

740025

TGFR2
TGF-beta receptor type-2

1

0

Small-scale

0.458

High

1271498

CC134
Coiled-coil domain-containing protein 134

1

0

Small-scale

0.458

High

1271499

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

Small-scale

0.458

High

1271515

EXO1
Exonuclease 1

1

0

Small-scale

0.458

High

839654

SERPH
Serpin H1

1

3

Small-scale

0.457

High

362342

B3AT
Band 3 anion transport protein

1

2

Small-scale

0.437

High

1068030

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.261

Low

1242257

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024