Protein: NCF1
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)

Gene: NCF1
Organism: Homo sapiens
Interactions: 107
UniProt ID: P14598

Gene Ontology (top 5):
GO:0001878 - response to yeast
GO:0002679 - respiratory burst involved in defense response
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572774

NCF2
Neutrophil cytosol factor 2

16

20

Small-scale

0.986

High

572830

NCF4
Neutrophil cytosol factor 4

4

19

Small-scale

0.894

High

572812

KPCZ
Protein kinase C zeta type

4

11

Small-scale

0.893

High

572788

PA24A
Cytosolic phospholipase A2

3

5

Small-scale

0.866

High

436599

KPCB
Protein kinase C beta type

3

11

Small-scale

0.827

High

572772

KPCA
Protein kinase C alpha type

2

11

Small-scale

0.755

High

562774

CY24A
Cytochrome b-245 light chain

5

3

Small-scale

0.720

High

572849

TRAF4
TNF receptor-associated factor 4

5

6

Small-scale

0.714

High

572847

SH3G1
Endophilin-A2

1

20

High-throughput

0.691

High

572841

ABI1
Abl interactor 1

1

20

Small-scale

0.683

High

572827

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.665

High

572776

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.665

High

572770

NCF1
Neutrophil cytosol factor 1

1

18

Small-scale

0.647

High

572840

SYTL1
Synaptotagmin-like protein 1

1

3

Small-scale

0.647

High

572798

ACTB
Actin, cytoplasmic 1

2

13

Small-scale

0.629

High

572784

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

Small-scale

0.625

High

572819

PAK1
Serine/threonine-protein kinase PAK 1

3

20

Small-scale

0.624

High

572838

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

19

High-throughput

0.621

High

572839

NOXA1
NADPH oxidase activator 1

1

4

Small-scale

0.621

High

572800

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

572848

SH3G3
Endophilin-A3

1

20

High-throughput

0.618

High

572811

TF65
Transcription factor p65

1

5

Small-scale

0.598

High

572853

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

Small-scale

0.586

High

572813

KPCD
Protein kinase C delta type

2

13

Small-scale

0.585

High

71265

NCF1C
Putative neutrophil cytosol factor 1C

1

17

High-throughput

0.575

High

117058

J3KT38
Growth factor receptor bound protein 2

1

20

High-throughput

0.575

High

572815

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

11

Small-scale

0.571

High

560950

GP1BB
Platelet glycoprotein Ib beta chain

1

2

Small-scale

0.561

High

572781

MOES
Moesin

1

8

Small-scale

0.561

High

572850

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

17

High-throughput

0.541

High

572804

ADAM8
Disintegrin and metalloproteinase domain-containing protein 8

1

20

Small-scale

0.536

High

405390

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.536

High

474444

VIME
Vimentin

1

10

High-throughput

0.536

High

565757

EF2
Elongation factor 2

1

3

High-throughput

0.536

High

572775

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.536

High

572780

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.536

High

572782

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

572793

COPB
Coatomer subunit beta

1

7

High-throughput

0.536

High

572794

COPA
Coatomer subunit alpha

1

2

High-throughput

0.536

High

572795

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.536

High

572796

SYMC
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.536

High

572814

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.536

High

572816

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.536

High

572817

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

1

High-throughput

0.536

High

572820

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.536

High

572832

RBBP7
Histone-binding protein RBBP7

1

3

High-throughput

0.536

High

572844

HS105
Heat shock protein 105 kDa

1

10

High-throughput

0.536

High

572855

RCC2
Protein RCC2

1

1

High-throughput

0.536

High

442220

GELS
Gelsolin

1

3

High-throughput

0.515

High

572786

HD
Huntingtin

1

1

High-throughput

0.515

High

572771

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.513

High

572778

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.513

High

572785

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

572790

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

572791

FAS
Fatty acid synthase

1

0

High-throughput

0.513

High

572802

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

572821

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

572824

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.513

High

572837

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.513

High

572846

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

572787

MK09
Mitogen-activated protein kinase 9

1

7

Small-scale

0.501

High

572789

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.501

High

572797

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

572805

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.501

High

572806

PKD1
Polycystin-1

1

4

Small-scale

0.501

High

572822

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

20

Small-scale

0.501

High

572823

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.501

High

572851

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

20

Small-scale

0.501

High

536415

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.500

High

572783

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

572810

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.489

High

572833

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.489

High

572835

NOM1
Nucleolar MIF4G domain-containing protein 1

1

2

High-throughput

0.489

High

572842

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.489

High

216314

MGA
Maltase-glucoamylase

1

1

Small-scale

0.481

High

519588

LYAG
Lysosomal alpha-glucosidase

1

1

Small-scale

0.481

High

572803

CSK2B
Casein kinase II subunit beta

1

3

Small-scale

0.481

High

572807

MYPC1
Myosin-binding protein C, slow-type

1

8

Small-scale

0.481

High

572808

SRSF2
Serine/arginine-rich splicing factor 2

1

11

Small-scale

0.481

High

572829

MYPC3
Myosin-binding protein C, cardiac-type

1

5

Small-scale

0.481

High

442568

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.480

High

160989

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.479

High

212707

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

12

Small-scale

0.479

High

416947

CY24B
NADPH oxidase 2

1

1

Small-scale

0.479

High

418580

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

1

Small-scale

0.479

High

572773

SYN1
Synapsin-1

1

18

Small-scale

0.479

High

572779

IL4RA
Interleukin-4 receptor subunit alpha

1

12

Small-scale

0.479

High

572799

ACTA
Actin, aortic smooth muscle

1

13

Small-scale

0.479

High

572801

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

Small-scale

0.479

High

572809

TAGL
Transgelin

1

7

Small-scale

0.479

High

572825

KEAP1
Kelch-like ECH-associated protein 1

1

7

Small-scale

0.479

High

572826

SRC8
Src substrate cortactin

1

19

Small-scale

0.479

High

572828

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

2

Small-scale

0.479

High

572831

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

572843

WASF1
Actin-binding protein WASF1

1

20

Small-scale

0.479

High

572852

GPVI
Platelet glycoprotein VI

1

3

Small-scale

0.479

High

284275

GEMI
Geminin

1

0

Small-scale

0.460

High

572854

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

468022

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.445

High

572845

PASK
PAS domain-containing serine/threonine-protein kinase

1

12

Small-scale

0.445

High

572836

Q6NSK7
RIN3 protein

1

20

High-throughput

0.417

High

572792

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

168184

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.279

Low

572777

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.279

Low

572818

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.279

Low

572834

Q32Q12
Nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025