Protein: FANCI
Fanconi anemia group I protein (Protein FACI)

Gene: FANCI
Organism: Homo sapiens
Interactions: 217
UniProt ID: Q9NVI1

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1417494

FACD2
Fanconi anemia group D2 protein

22

3

Small-scale

0.988

High

1347159

WDR48
WD repeat-containing protein 48

3

1

Small-scale

0.861

High

1450550

FANCL
E3 ubiquitin-protein ligase FANCL

8

3

Small-scale

0.745

High

1450549

FANCI
Fanconi anemia group I protein

2

0

Small-scale

0.728

High

317223

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

4

1

Small-scale

0.694

High

1420022

UBL5
Ubiquitin-like protein 5

1

0

Small-scale

0.687

High

373281

MYC
Myc proto-oncogene protein

4

0

High-throughput

0.653

High

1104511

ILK
Scaffold protein ILK

3

0

High-throughput

0.643

High

1145541

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.618

High

1338992

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.618

High

218840

TGON2
Trans-Golgi network integral membrane protein 2

3

0

High-throughput

0.606

High

1382392

SPSB4
SPRY domain-containing SOCS box protein 4

2

2

High-throughput

0.601

High

1387589

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.586

High

1399971

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.586

High

1114430

CUL3
Cullin-3

2

0

High-throughput

0.585

High

981132

H2B1C
Histone H2B type 1-C/E/F/G/I

2

1

High-throughput

0.584

High

1450567

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.565

High

297693

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.561

High

1314442

SLX4
Structure-specific endonuclease subunit SLX4

2

0

High-throughput

0.559

High

1450563

FAN1
Fanconi-associated nuclease 1

2

0

Small-scale

0.559

High

631510

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

412691

NTRK1
High affinity nerve growth factor receptor

2

5

High-throughput

0.543

High

728446

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.537

High

182802

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

380663

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.536

High

521031

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

939977

TPTE
Putative tyrosine-protein phosphatase TPTE

1

1

High-throughput

0.536

High

1401835

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

1

High-throughput

0.536

High

1405982

SPSB2
SPRY domain-containing SOCS box protein 2

1

2

High-throughput

0.536

High

1428918

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

1

High-throughput

0.536

High

1450559

CLC2D
C-type lectin domain family 2 member D

1

2

High-throughput

0.536

High

1450560

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.536

High

277414

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.515

High

1438784

NEK6
Serine/threonine-protein kinase Nek6

1

1

High-throughput

0.515

High

211513

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

0

High-throughput

0.513

High

225705

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

348763

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.513

High

374970

RASH
GTPase HRas

1

0

High-throughput

0.513

High

634811

GRAH
Granzyme H

1

0

High-throughput

0.513

High

777023

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

813236

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

905690

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1101195

CLN3
Battenin

1

0

High-throughput

0.513

High

1154512

STXB2
Syntaxin-binding protein 2

1

0

High-throughput

0.513

High

1161235

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

1293538

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.513

High

1336071

ARRD4
Arrestin domain-containing protein 4

1

0

High-throughput

0.513

High

1349132

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1351255

HELQ
Helicase POLQ-like

1

0

Small-scale

0.513

High

1361776

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1394734

PKHA8
Pleckstrin homology domain-containing family A member 8

1

0

High-throughput

0.513

High

1420168

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1420465

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.513

High

1450554

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.513

High

1450555

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

1450562

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.513

High

1450566

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

High-throughput

0.513

High

1450569

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1055981

RAD51
DNA repair protein RAD51 homolog 1

1

2

Small-scale

0.501

High

1109519

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.501

High

363924

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.500

High

465667

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.500

High

484230

PGFRB
Platelet-derived growth factor receptor beta

1

9

High-throughput

0.500

High

541714

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.500

High

641270

FGFR2
Fibroblast growth factor receptor 2

1

11

High-throughput

0.500

High

710902

EPHB2
Ephrin type-B receptor 2

1

3

High-throughput

0.500

High

932144

EPHA4
Ephrin type-A receptor 4

1

4

High-throughput

0.500

High

1157086

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.500

High

156085

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.493

High

1437816

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.493

High

1450564

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

1450568

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.493

High

936132

PAR2
Proteinase-activated receptor 2

1

1

High-throughput

0.489

High

1090116

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

3

High-throughput

0.489

High

1098946

KLRD1
Natural killer cells antigen CD94

1

3

High-throughput

0.489

High

1101314

SLAF1
Signaling lymphocytic activation molecule

1

3

High-throughput

0.489

High

1142194

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

1291911

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.489

High

1161072

FSCN1
Fascin

1

0

Small-scale

0.483

High

423296

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

247445

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

Small-scale

0.479

High

257002

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

487807

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

610056

VGFR1
Vascular endothelial growth factor receptor 1

1

6

High-throughput

0.479

High

622688

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.479

High

630368

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

670021

MCM3
DNA replication licensing factor MCM3

1

2

Small-scale

0.479

High

756068

MCM5
DNA replication licensing factor MCM5

1

1

Small-scale

0.479

High

777778

VGFR3
Vascular endothelial growth factor receptor 3

1

7

High-throughput

0.479

High

827499

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.479

High

861804

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

888348

MCM2
DNA replication licensing factor MCM2

1

2

Small-scale

0.479

High

928715

PMS2
Mismatch repair endonuclease PMS2

1

1

Small-scale

0.479

High

998863

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017249

H33
Histone H3.3

1

1

High-throughput

0.479

High

1052855

DUSP2
Dual specificity protein phosphatase 2

1

1

High-throughput

0.479

High

1102273

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

1106092

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1201903

PKHG4
Puratrophin-1

1

1

High-throughput

0.479

High

1239792

FAP20
Fanconi anemia core complex-associated protein 20

1

1

High-throughput

0.479

High

1251962

LMTK1
Serine/threonine-protein kinase LMTK1

1

6

High-throughput

0.479

High

1256838

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

1

Small-scale

0.479

High

1280546

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1324601

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.479

High

1331566

CE120
Centrosomal protein of 120 kDa

1

1

High-throughput

0.479

High

1403261

RSF1
Remodeling and spacing factor 1

1

1

Small-scale

0.479

High

1414916

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

904391

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.460

High

129474

MEN1
Menin

1

0

High-throughput

0.458

High

157913

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

159877

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

180068

BET1
BET1 homolog

1

0

High-throughput

0.458

High

260522

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

294408

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

331357

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

337399

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.458

High

409100

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

473122

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

521447

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.458

High

582629

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.458

High

589834

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

591859

H2AX
Histone H2AX

1

0

High-throughput

0.458

High

643095

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

664819

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

693109

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

696654

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

731642

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

769321

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799512

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

831515

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

840807

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.458

High

895103

EMD
Emerin

1

0

High-throughput

0.458

High

927153

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

935188

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

947289

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

959272

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

971165

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

979291

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

982848

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

985026

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1005151

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1033795

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1107263

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1111309

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.458

High

1117075

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.458

High

1152482

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

1155823

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1161415

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1178418

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1218672

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1229709

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1252991

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1255773

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1279421

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

1313465

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1314877

FANCM
Fanconi anemia group M protein

1

0

Small-scale

0.458

High

1334988

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1364624

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1366591

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1397482

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1399007

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

1403592

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1404445

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1411953

PELO
Protein pelota homolog

1

0

High-throughput

0.458

High

1418814

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

1428452

SENP6
Sentrin-specific protease 6

1

0

Small-scale

0.458

High

1434027

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435351

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1437997

PIDD1
p53-induced death domain-containing protein 1

1

0

Small-scale

0.458

High

1438183

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.458

High

1446241

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

Small-scale

0.458

High

1448204

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1450551

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1450552

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1450556

REV1
DNA repair protein REV1

1

0

Small-scale

0.458

High

1450557

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1450558

SEPT9
Septin-9

1

0

Small-scale

0.458

High

1450565

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1055102

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

7

High-throughput

0.457

High

157

A0A024R6X4
PLEKHG4

1

1

High-throughput

0.445

High

104235

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

171594

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.445

High

380167

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

1240971

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

1243669

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.445

High

650450

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.437

High

720340

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.437

High

787088

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

6

High-throughput

0.437

High

1313857

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

127195

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

510101

S35E2
Solute carrier family 35 member E2A

1

0

High-throughput

0.426

High

1092669

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

1130482

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

116521

H7C2E6
FA core complex associated protein 20

1

1

High-throughput

0.407

High

887263

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

139335

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

168128

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

0

High-throughput

0.279

Low

260975

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

1009338

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1350900

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1399630

OPALI
Opalin

1

0

High-throughput

0.279

Low

1430980

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1434652

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1446713

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1450561

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

1414740

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.269

Low

880971

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

553875

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.249

Low

1186149

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

1203092

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1249259

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1276858

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1286931

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

1450553

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low

1140

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1335750

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025