Protein: RN146
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)

Gene: RN146, RNF146
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9NTX7

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957213

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

2

Small-scale

0.806

High

1449654

RN146
E3 ubiquitin-protein ligase RNF146

3

0

Small-scale

0.792

High

1449658

PARP2
Poly [ADP-ribose] polymerase 2

6

3

Small-scale

0.727

High

332452

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

5

1

Small-scale

0.726

High

487803

PARP1
Poly [ADP-ribose] polymerase 1

5

4

Small-scale

0.726

High

906795

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.710

High

952475

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

3

High-throughput

0.698

High

971156

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.698

High

892633

DNLI3
DNA ligase 3

5

0

Small-scale

0.679

High

1292517

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

5

0

Small-scale

0.679

High

1065455

SSRP1
FACT complex subunit SSRP1

4

0

Small-scale

0.661

High

1449663

SP16H
FACT complex subunit SPT16

4

0

Small-scale

0.661

High

982335

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

Small-scale

0.647

High

1090945

TRAF2
TNF receptor-associated factor 2

3

0

High-throughput

0.646

High

1432020

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

3

1

Small-scale

0.640

High

832950

CETN2
Centrin-2

3

0

High-throughput

0.638

High

1032874

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

1127772

HLTF
Helicase-like transcription factor

4

0

Small-scale

0.638

High

617743

XRCC1
DNA repair protein XRCC1

3

0

Small-scale

0.628

High

1449662

AXIN2
Axin-2

2

1

Small-scale

0.601

High

1307329

H2A2B
Histone H2A type 2-B

1

0

High-throughput

0.586

High

173436

XPO1
Exportin-1

2

1

Small-scale

0.584

High

1413941

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

2

0

High-throughput

0.580

High

558438

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

1449657

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.549

High

987235

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

Small-scale

0.546

High

1280544

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.546

High

762498

PROF2
Profilin-2

1

0

High-throughput

0.518

High

1197103

AMOT
Angiomotin

1

2

Small-scale

0.515

High

1314107

AMOL1
Angiomotin-like protein 1

1

2

Small-scale

0.515

High

1341106

INADL
InaD-like protein

1

5

Small-scale

0.515

High

1449660

AMOL2
Angiomotin-like protein 2

1

2

Small-scale

0.515

High

1432836

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.513

High

181182

AXIN1
Axin-1

1

1

Small-scale

0.479

High

239430

3BP5
SH3 domain-binding protein 5

1

1

Small-scale

0.479

High

299800

MPDZ
Multiple PDZ domain protein

1

5

Small-scale

0.479

High

334921

IPO7
Importin-7

1

1

Small-scale

0.479

High

559519

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

767353

MERL
Merlin

1

1

Small-scale

0.479

High

801552

HSPA9
Stress-70 protein, mitochondrial

1

1

Small-scale

0.479

High

878568

PAXI
Paxillin

1

1

Small-scale

0.479

High

936461

AFAD
Afadin

1

4

Small-scale

0.479

High

1116601

FHL3
Four and a half LIM domains protein 3

1

1

Small-scale

0.479

High

1122357

SCRIB
Protein scribble homolog

1

2

Small-scale

0.479

High

1146353

L2GL1
Lethal(2) giant larvae protein homolog 1

1

1

Small-scale

0.479

High

1241047

L2GL2
LLGL scribble cell polarity complex component 2

1

1

Small-scale

0.479

High

1272918

3BP5L
SH3 domain-binding protein 5-like

1

1

Small-scale

0.479

High

1394169

AJUBA
LIM domain-containing protein ajuba

1

1

Small-scale

0.479

High

1418668

PAR6G
Partitioning defective 6 homolog gamma

1

2

Small-scale

0.479

High

1428451

SENP6
Sentrin-specific protease 6

1

2

Small-scale

0.479

High

1438697

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.479

High

1446170

PAR6A
Partitioning defective 6 homolog alpha

1

2

Small-scale

0.479

High

1449656

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.479

High

1449661

FRM4B
FERM domain-containing protein 4B

1

2

Small-scale

0.479

High

134162

IPO5
Importin-5

1

0

Small-scale

0.458

High

221811

SNAI2
Zinc finger protein SNAI2

1

0

Small-scale

0.458

High

457732

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

535588

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

596380

H12
Histone H1.2

1

0

Small-scale

0.458

High

620615

NUCL
Nucleolin

1

0

Small-scale

0.458

High

621533

HXK1
Hexokinase-1

1

0

Small-scale

0.458

High

668730

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.458

High

680524

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

951871

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1027788

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

1045822

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

1051324

KPCZ
Protein kinase C zeta type

1

0

Small-scale

0.458

High

1114419

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1154458

STK11
Serine/threonine-protein kinase STK11

1

0

Small-scale

0.458

High

1391425

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.458

High

1398151

NSE2
E3 SUMO-protein ligase NSE2

1

0

Small-scale

0.458

High

1431869

GO45
Golgin-45

1

0

Small-scale

0.458

High

1446397

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1449664

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.458

High

637756

FLNA
Filamin-A

1

1

Small-scale

0.445

High

814874

CUX1
Homeobox protein cut-like 1

1

1

Small-scale

0.445

High

1090193

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

Small-scale

0.445

High

1091579

DLG1
Disks large homolog 1

1

1

Small-scale

0.445

High

1212214

MPP7
MAGUK p55 subfamily member 7

1

1

Small-scale

0.445

High

1215979

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

5

Small-scale

0.445

High

1449655

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

1

Small-scale

0.445

High

1278125

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.437

High

207666

DHX15
ATP-dependent RNA helicase DHX15

1

0

Small-scale

0.426

High

369277

ANT3
Antithrombin-III

1

0

High-throughput

0.426

High

589813

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.426

High

696631

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.426

High

770063

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.426

High

834542

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.426

High

841980

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.426

High

862999

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.426

High

1008378

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.426

High

1028896

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

Small-scale

0.426

High

1122956

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

0

Small-scale

0.426

High

1157955

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.426

High

1202012

H90B4
Putative heat shock protein HSP 90-beta 4

1

0

High-throughput

0.426

High

1210744

ZMYM1
Zinc finger MYM-type protein 1

1

0

Small-scale

0.426

High

1290988

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.426

High

1369782

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.426

High

1402255

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.426

High

1403541

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.426

High

1411419

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.426

High

1449659

RUVB2
RuvB-like 2

1

0

Small-scale

0.426

High

1329446

KASH5
Protein KASH5

4

0

High-throughput

0.369

High

301725

WFS1
Wolframin

1

0

High-throughput

0.268

Low

891047

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.268

Low

1004316

3BP2
SH3 domain-binding protein 2

1

0

Small-scale

0.249

Low

1435090

WDCP
WD repeat and coiled-coil-containing protein

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025