Protein: MMP12
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)

Gene: MMP12
Organism: Homo sapiens
Interactions: 16
UniProt ID: P39900

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001046 - core promoter sequence-specific DNA binding
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0004252 - serine-type endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

590829

TIMP2
Metalloproteinase inhibitor 2

1

20

High-throughput

0.618

High

584619

ELN
Elastin

2

20

Small-scale

0.585

High

421633

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

462277

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.493

High

814898

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

390322

CXCL7
Platelet basic protein

1

20

Small-scale

0.445

High

480488

GROA
Growth-regulated alpha protein

1

20

Small-scale

0.445

High

518769

IL8
Interleukin-8

1

20

Small-scale

0.445

High

562835

CCL2
C-C motif chemokine 2

1

5

Small-scale

0.445

High

626423

CXCL2
C-X-C motif chemokine 2

1

20

Small-scale

0.445

High

626440

CXCL3
C-X-C motif chemokine 3

1

20

Small-scale

0.445

High

814894

CXCL5
C-X-C motif chemokine 5

1

20

Small-scale

0.445

High

814895

CCL8
C-C motif chemokine 8

1

5

Small-scale

0.445

High

814896

CCL7
C-C motif chemokine 7

1

5

Small-scale

0.445

High

814897

CXCL6
C-X-C motif chemokine 6

1

20

Small-scale

0.445

High

814899

CCL13
C-C motif chemokine 13

1

5

Small-scale

0.445

High


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Last updated: 11Aug2025