HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: EM55 (Q00013)
55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)
Gene: MPP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_1, PDZ~PDZ, SH3_1~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030863 - cortical cytoskeleton
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 466
+	Mm
		1223777 DLG4_MOUSE (1-724): 0: 660: 99.59		MPP2_MOUSE (12-466): 5.71e-136: 404: 37.08
+	Hs
		168670 DLG4_HUMAN (1-724): 0: 660: 100.00		CSKP_HUMAN (19-466): 2.03e-124: 385: 49.21
+	Hs
		168730 DLG3_HUMAN (28-724): 0: 593: 64.92		CSKP_HUMAN (19-466): 2.03e-124: 385: 49.21
+	Mm
		1223542 DLG4_MOUSE (1-724): 0: 660: 99.59		DLG4_MOUSE (14-154): 7.23e-20: 94.5: 13.51
+	Mm
		1223689 DLG4_MOUSE (1-724): 0: 660: 99.59		DLG2_MOUSE (34-153): 9.1e-20: 94.5: 18.90
+	Hs
		1006071 DLG4_HUMAN (1-724): 0: 660: 100.00		DLG2_HUMAN (34-153): 1.24e-19: 94.2: 18.90
+	Hs
		1006042 DLG4_HUMAN (1-724): 0: 660: 100.00		DLG4_HUMAN (6-182): 1.79e-19: 93.4: 17.94
+	Mm
		1190725 DLG4_MOUSE (1-724): 0: 660: 99.59		Q3UP61_MOUSE (6-217): 4.58e-18: 89.1: 15.63
+	Mm
		1223608 DLG4_MOUSE (1-724): 0: 660: 99.59		DLG1_MOUSE (6-217): 1.03e-17: 88: 15.63
+	Rn
		723883 DLG4_RAT (1-724): 0: 661: 99.86		DLG1_RAT (6-217): 2.06e-15: 81.1: 14.29
+	Rn
		723886 DLG4_RAT (1-724): 0: 661: 99.86		DLG3_RAT (44-141): 1.19e-14: 78.4: 19.30
+	Mm
		999787 DLG4_MOUSE (1-724): 0: 660: 99.59		DLG3_MOUSE (44-141): 1.26e-14: 78.4: 19.30
+	Hs
		1006087 DLG4_HUMAN (1-724): 0: 660: 100.00		DLG3_HUMAN (71-141): 5.77e-14: 76.4: 20.51
+	Mm
		1197968 DLG4_MOUSE (1-724): 0: 660: 99.59		Q52KF7_MOUSE (71-141): 5.77e-14: 76.4: 20.51
+	Hs
		1152416 DLG3_HUMAN (28-724): 0: 593: 64.92		DLG2_HUMAN (34-153): 1.24e-19: 94.2: 18.90
+	Hs
		1091548 DLG3_HUMAN (28-724): 0: 593: 64.92		DLG1_HUMAN (6-226): 1.11e-17: 88: 13.60
+	Mm
		999796 DLG3_MOUSE (8-724): 0: 584: 62.67		DLG2_MOUSE (34-153): 9.1e-20: 94.5: 18.90