HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: FRPD4 (Q14CM0)
FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)
Gene: FRMPD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0043197 - dendritic spine
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 1322
+	Mm
		59272 DLG4_MOUSE (1-724): 0: 660: 99.59		FRPD4_MOUSE (1-1322): 0: 2167: 90.70
+	Hs
		1135552 DLG3_HUMAN (28-724): 0: 593: 64.92		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Hs
		1091495 DLG1_HUMAN (32-724): 0: 572: 73.33		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Hs
		1122225 SCRIB_HUMAN (58-243): 6.13e-25: 113: 40.72		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Mm
		757457 DLG4_MOUSE (1-724): 0: 660: 99.59		FAK1_MOUSE (202-540): 1.15e-68: 253: 23.18
+	Hs
		1006062 DLG4_HUMAN (1-724): 0: 660: 100.00		FAK2_HUMAN (191-539): 1.74e-66: 246: 20.87
+	Mm
		3698 DLG4_MOUSE (1-724): 0: 660: 99.59		A0A140LIW3_MOUSE (776-940): 1.26e-63: 241: 47.65
+	Hs
		1125290 DLG3_HUMAN (28-724): 0: 593: 64.92		FAK2_HUMAN (191-539): 1.74e-66: 246: 20.87
+	Mm
		1223740 DLG4_MOUSE (1-724): 0: 660: 99.59		MAGI3_MOUSE (14-161): 3.19e-39: 161: 23.94
+	Mm
		1223628 DLG4_MOUSE (1-724): 0: 660: 99.59		Q8BXG0_MOUSE (193-312): 2.26e-41: 150: 56.67
+	Hs
		1122251 SCRIB_HUMAN (58-243): 6.13e-25: 113: 40.72		FRPD1_HUMAN (62-539): 2e-144: 480: 49.38
+	Hs
		1325307 PALS1_HUMAN (19-331): 1.53e-16: 85.9: 10.90		MAGI1_HUMAN (14-158): 1.22e-25: 117: 17.50