HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25499913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~WD40
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1298
+	Hs
		965190 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		964840 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		1395137 TCPH_HUMAN (4-532): 0: 591: 34.08		DCAF5_HUMAN (13-774): 1.19e-70: 258: 14.37
+	Hs
		881861 TCPG_HUMAN (3-532): 0: 561: 28.33		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		1007205 TCPB_HUMAN (1-535): 0: 586: 100.00		DCAF5_HUMAN (13-774): 1.19e-70: 258: 14.37
+	Hs
		1291941 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		1007118 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		1007196 TCPB_HUMAN (1-535): 0: 586: 100.00		SNR40_HUMAN (45-334): 1.8e-54: 196: 12.04
+	Hs
		1334162 TCPH_HUMAN (4-532): 0: 591: 34.08		POC1A_HUMAN (83-434): 1.48e-41: 160: 12.30
+	Hs
		1007146 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1A_HUMAN (83-434): 1.48e-41: 160: 12.30
+	Hs
		284939 TCPB_HUMAN (1-535): 0: 586: 100.00		TAF5L_HUMAN (57-304): 2.69e-36: 148: 15.14
+	Sc
		793919 TCPB_YEAST (9-532): 0: 566: 65.71		TAF5_YEAST (9-127): 1.1e-32: 139: 22.22
+	Hs
		845257 TCPG_HUMAN (3-532): 0: 561: 28.33		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	Hs
		1407542 TCPH_HUMAN (4-532): 0: 591: 34.08		KTNB1_HUMAN (167-610): 4.74e-17: 88.7: 8.64
+	Hs
		1007186 TCPB_HUMAN (1-535): 0: 586: 100.00		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		1007244 TCPB_HUMAN (1-535): 0: 586: 100.00		KTNB1_HUMAN (167-610): 4.74e-17: 88.7: 8.64
+	Hs
		1007162 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1B_HUMAN (1-83): 2.36e-16: 85.7: 16.28
+	Hs
		1407533 TCPH_HUMAN (4-532): 0: 591: 34.08		TBL1Y_HUMAN (5-169): 1.79e-13: 76.7: 21.67
+	Hs
		1007231 TCPB_HUMAN (1-535): 0: 586: 100.00		TBL1Y_HUMAN (5-169): 1.79e-13: 76.7: 21.67
+	Sc
		810735 TCPB_YEAST (9-532): 0: 566: 65.71		COPA_YEAST (12-143): 2.59e-16: 87.1: 16.43