Protein: TCPB
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)

Gene: TCPB, CCT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 239
UniProt ID: P39076

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005832 - chaperonin-containing T-complex
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810683

TCPG
T-complex protein 1 subunit gamma

5

19

Small-scale

0.898

High

810743

2ABA
Protein phosphatase PP2A regulatory subunit B

3

20

High-throughput

0.861

High

553993

TCPA
T-complex protein 1 subunit alpha

3

17

Small-scale

0.857

High

810795

CMR1
DNA damage-binding protein CMR1

3

20

High-throughput

0.847

High

810684

TCPD
T-complex protein 1 subunit delta

3

19

High-throughput

0.830

High

810709

TCPH
T-complex protein 1 subunit eta

2

19

High-throughput

0.789

High

810685

TCPZ
T-complex protein 1 subunit zeta

2

19

High-throughput

0.754

High

793919

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

2

20

High-throughput

0.726

High

781871

CAF4
CCR4-associated factor 4

2

20

High-throughput

0.705

High

633466

PP11
Serine/threonine-protein phosphatase PP1-1

4

20

High-throughput

0.697

High

617392

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.691

High

637218

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.691

High

810686

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.691

High

754278

DCA13
Protein SOF1

1

20

High-throughput

0.618

High

810696

UTP7
U3 small nucleolar RNA-associated protein 7

1

20

High-throughput

0.618

High

810705

COPB2
Coatomer subunit beta'

1

20

High-throughput

0.618

High

810708

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.618

High

810783

RAD28
Radiation-sensitive protein 28

1

20

High-throughput

0.618

High

486177

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.618

High

486460

TBA3
Tubulin alpha-3 chain

1

20

High-throughput

0.618

High

792049

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

802062

ARP1
Centractin

1

20

High-throughput

0.618

High

810701

TCPE
T-complex protein 1 subunit epsilon

1

19

High-throughput

0.618

High

810719

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.618

High

810756

PLP1
Phosducin-like protein 1

1

18

High-throughput

0.618

High

684618

CDC20
APC/C activator protein CDC20

2

20

Small-scale

0.611

High

810699

VID27
Vacuolar import and degradation protein 27

2

3

High-throughput

0.611

High

810734

CDH1
APC/C activator protein CDH1

2

20

Small-scale

0.611

High

810782

PLP2
Phosducin-like protein 2

2

20

High-throughput

0.611

High

810791

WTM1
Transcriptional modulator WTM1

2

3

High-throughput

0.611

High

544893

SSB1
Ribosome-associated molecular chaperone SSB1

2

15

High-throughput

0.584

High

579400

HSC82
ATP-dependent molecular chaperone HSC82

2

16

High-throughput

0.584

High

810724

HGH1
Protein HGH1

2

3

Small-scale

0.584

High

810704

DSN1
Kinetochore-associated protein DSN1

3

3

High-throughput

0.578

High

567722

MSI1
Histone-binding protein MSI1

1

20

High-throughput

0.575

High

810715

AIP1
Actin-interacting protein 1

1

20

High-throughput

0.575

High

810741

ACT
Actin

1

20

Small-scale

0.575

High

810731

HOS2
Probable histone deacetylase HOS2

2

20

High-throughput

0.571

High

795347

ATG8
Autophagy-related protein 8

1

20

Small-scale

0.561

High

810717

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.553

High

523967

HSP71
Heat shock protein SSA1

2

13

High-throughput

0.552

High

810730

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.546

High

574682

KSS1
Mitogen-activated protein kinase KSS1

1

16

High-throughput

0.536

High

734853

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.536

High

740578

IME2
Meiosis induction protein kinase IME2/SME1

1

15

High-throughput

0.536

High

745973

PP2A4
Serine/threonine-protein phosphatase PP2A-like PPG1

1

20

High-throughput

0.536

High

778882

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

15

High-throughput

0.536

High

810737

BRE5
UBP3-associated protein BRE5

1

7

High-throughput

0.536

High

810747

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.536

High

810781

NEW1
[NU+] prion formation protein 1

1

1

High-throughput

0.536

High

810778

ESA1
Histone acetyltransferase ESA1

2

3

Small-scale

0.534

High

734099

EF2
Elongation factor 2

2

9

Small-scale

0.533

High

810713

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

11

High-throughput

0.533

High

382102

H4
Histone H4

2

3

High-throughput

0.521

High

810742

H3
Histone H3

2

9

High-throughput

0.521

High

808368

SEC31
Protein transport protein SEC31

1

20

High-throughput

0.514

High

810735

COPA
Coatomer subunit alpha

1

20

High-throughput

0.514

High

810770

CORO
Coronin-like protein

1

20

High-throughput

0.514

High

810771

UTP4
U3 small nucleolar RNA-associated protein 4

1

20

High-throughput

0.514

High

598480

SEN2
tRNA-splicing endonuclease subunit SEN2

1

0

High-throughput

0.513

High

810721

DOHH
Deoxyhypusine hydroxylase

1

0

High-throughput

0.513

High

481626

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.500

High

645735

HSP74
Heat shock protein SSA4

1

13

High-throughput

0.500

High

739867

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.500

High

762959

SPT7
SAGA complex subunit SPT7

1

8

High-throughput

0.489

High

795664

MOH1
Protein yippee-like MOH1

1

2

High-throughput

0.489

High

807217

SPT8
SAGA complex subunit SPT8

1

3

High-throughput

0.489

High

572583

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

590628

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

392737

HSP82
ATP-dependent molecular chaperone HSP82

1

16

High-throughput

0.479

High

435094

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

592257

VATB
V-type proton ATPase subunit B

1

12

High-throughput

0.479

High

603469

VATA
V-type proton ATPase catalytic subunit A

1

17

High-throughput

0.479

High

660790

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

20

High-throughput

0.479

High

670713

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

674626

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

679685

CDC48
Cell division control protein 48

1

9

High-throughput

0.479

High

682278

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.479

High

709754

BMH1
Protein BMH1

1

3

High-throughput

0.479

High

727028

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

734983

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

747852

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

776574

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

794871

MAP2
Methionine aminopeptidase 2

1

7

High-throughput

0.479

High

810690

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

810726

VATG
V-type proton ATPase subunit G

1

3

High-throughput

0.479

High

810752

TOM1
E3 ubiquitin-protein ligase TOM1

1

15

High-throughput

0.479

High

810757

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.479

High

810763

YMW4
Uncharacterized protein YMR074C

1

8

High-throughput

0.479

High

810777

SGO1
Shugoshin

1

3

High-throughput

0.479

High

810793

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.479

High

810797

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

810706

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

359475

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.457

High

405091

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.457

High

701525

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.457

High

705766

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

3

High-throughput

0.457

High

359227

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

6

High-throughput

0.445

High

365622

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.445

High

394565

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

430851

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

High-throughput

0.445

High

438536

UBC2
Ubiquitin-conjugating enzyme E2 2

1

1

High-throughput

0.445

High

510493

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

526709

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

557594

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

11

High-throughput

0.445

High

574798

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

4

High-throughput

0.445

High

632672

DBP4
ATP-dependent RNA helicase HCA4

1

5

High-throughput

0.445

High

645927

DBF2
Cell cycle protein kinase DBF2

1

11

High-throughput

0.445

High

735456

AAR2
A1 cistron-splicing factor AAR2

1

5

High-throughput

0.445

High

746093

RAD5
DNA repair protein RAD5

1

3

High-throughput

0.445

High

778936

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

14

High-throughput

0.445

High

779057

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.445

High

779125

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.445

High

809180

END3
Actin cytoskeleton-regulatory complex protein END3

1

3

High-throughput

0.445

High

810687

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.445

High

810693

ARB1
ABC transporter ATP-binding protein ARB1

1

1

High-throughput

0.445

High

810698

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

810718

MTR4
ATP-dependent RNA helicase DOB1

1

2

High-throughput

0.445

High

810722

GPN1
GPN-loop GTPase 1

1

2

High-throughput

0.445

High

810725

GYP7
GTPase-activating protein GYP7

1

1

High-throughput

0.445

High

810729

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

4

High-throughput

0.445

High

810732

INO80
Chromatin-remodeling ATPase INO80

1

3

High-throughput

0.445

High

810745

ACAC
Acetyl-CoA carboxylase

1

3

High-throughput

0.445

High

810746

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

18

High-throughput

0.445

High

810751

ESP1
Separin

1

2

High-throughput

0.445

High

810790

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.445

High

810792

NAA25
N-terminal acetyltransferase B complex subunit MDM20

1

2

High-throughput

0.445

High

410136

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433643

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

503046

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

512442

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

647112

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.437

High

660854

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

20

High-throughput

0.437

High

677397

KRR1
KRR1 small subunit processome component

1

3

High-throughput

0.437

High

707112

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

747366

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

763889

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

764075

SPT21
Protein SPT21

1

2

High-throughput

0.437

High

779230

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.437

High

805540

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

19

Small-scale

0.437

High

810688

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

810710

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

810744

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.437

High

810762

POB3
FACT complex subunit POB3

1

2

High-throughput

0.437

High

810767

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

810768

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.437

High

365051

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

366022

INV2
Invertase 2

1

0

High-throughput

0.426

High

366053

CBPY
Carboxypeptidase Y

1

0

High-throughput

0.426

High

366713

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.426

High

448966

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.426

High

452506

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.426

High

569787

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

575252

RAD4
DNA repair protein RAD4

1

0

High-throughput

0.426

High

666658

AP2
AP-1-like transcription factor YAP2

1

0

High-throughput

0.426

High

672103

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.426

High

701648

OPLA
5-oxoprolinase

1

0

High-throughput

0.426

High

721940

XPO1
Exportin-1

1

0

High-throughput

0.426

High

726215

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.426

High

735426

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.426

High

781507

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.426

High

790445

PAM1
Protein PAM1

1

0

High-throughput

0.426

High

804082

GIC1
GTPase-interacting component 1

1

0

High-throughput

0.426

High

809041

POP2
Poly(A) ribonuclease POP2

1

0

High-throughput

0.426

High

810689

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.426

High

810692

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.426

High

810694

VHR2
Transcription factor VHR2

1

0

High-throughput

0.426

High

810700

ATG3
Autophagy-related protein 3

1

0

High-throughput

0.426

High

810711

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.426

High

810714

IGD1
Inhibitor of glycogen debranching 1

1

0

High-throughput

0.426

High

810720

YAE1
Protein YAE1

1

0

High-throughput

0.426

High

810728

YG51
Uncharacterized protein YGR237C

1

0

High-throughput

0.426

High

810739

NSG2
Protein NSG2

1

0

High-throughput

0.426

High

810754

CWC21
Pre-mRNA-splicing factor CWC21

1

0

High-throughput

0.426

High

810758

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.426

High

810759

GYL1
Probable GTPase-activating protein GYL1

1

0

High-throughput

0.426

High

810772

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.426

High

810774

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.426

High

810775

PML1
Pre-mRNA leakage protein 1

1

0

High-throughput

0.426

High

810780

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.426

High

810789

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.426

High

810794

STB3
Protein STB3

1

0

High-throughput

0.426

High

368167

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.407

High

402005

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.407

High

561312

DPOLA
DNA polymerase alpha catalytic subunit A

1

3

High-throughput

0.407

High

561706

HAP3
Transcriptional activator HAP3

1

1

High-throughput

0.407

High

562958

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.407

High

622361

ACON
Aconitate hydratase, mitochondrial

1

2

High-throughput

0.407

High

625011

PRP6
Pre-mRNA-splicing factor 6

1

7

High-throughput

0.407

High

672156

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

High-throughput

0.407

High

763323

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.407

High

805180

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

2

High-throughput

0.407

High

810691

RPN3
26S proteasome regulatory subunit RPN3

1

1

High-throughput

0.407

High

810702

NU159
Nucleoporin NUP159

1

1

High-throughput

0.407

High

810707

YN60
Uncharacterized membrane protein YNL320W

1

3

High-throughput

0.407

High

810727

LYS4
Homoaconitase, mitochondrial

1

2

High-throughput

0.407

High

810736

PRA1
Prenylated Rab acceptor 1

1

1

High-throughput

0.407

High

810749

ARL3
ADP-ribosylation factor-like protein 3

1

5

High-throughput

0.407

High

810750

SPP1
COMPASS component SPP1

1

1

High-throughput

0.407

High

810753

JIP4
Uncharacterized protein JIP4

1

1

High-throughput

0.407

High

810761

DPB4
DNA polymerase epsilon subunit D

1

1

High-throughput

0.407

High

810764

RRP5
rRNA biogenesis protein RRP5

1

7

High-throughput

0.407

High

810765

UTP21
U3 small nucleolar RNA-associated protein 21

1

20

High-throughput

0.407

High

810779

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.407

High

810784

AP1G1
AP-1 complex subunit gamma-1

1

2

High-throughput

0.407

High

810787

SCC1
Sister chromatid cohesion protein 1

1

4

High-throughput

0.407

High

810788

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

3

High-throughput

0.407

High

810796

SET6
Potential protein lysine methyltransferase SET6

1

3

High-throughput

0.407

High

810798

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.407

High

810769

ESF1
Pre-rRNA-processing protein ESF1

2

0

High-throughput

0.307

High

810773

THI3
Thiamine metabolism regulatory protein THI3

2

0

High-throughput

0.307

High

439131

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

314871

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.232

Low

582466

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.232

Low

605958

GABAT
4-aminobutyrate aminotransferase

1

0

High-throughput

0.232

Low

609224

CLC1
Clathrin light chain

1

0

High-throughput

0.232

Low

644701

AEP2
ATPase expression protein 2, mitochondrial

1

0

High-throughput

0.232

Low

699501

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.232

Low

740408

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.232

Low

753237

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.232

Low

757486

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

High-throughput

0.232

Low

794349

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.232

Low

807071

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.232

Low

810695

ICP55
Intermediate cleaving peptidase 55

1

0

High-throughput

0.232

Low

810697

IES5
Ino eighty subunit 5

1

0

High-throughput

0.232

Low

810703

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.232

Low

810712

IES1
Ino eighty subunit 1

1

0

High-throughput

0.232

Low

810716

GON7
EKC/KEOPS complex subunit GON7

1

0

High-throughput

0.232

Low

810723

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.232

Low

810733

GET1
Golgi to ER traffic protein 1

1

0

High-throughput

0.232

Low

810738

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.232

Low

810740

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.232

Low

810748

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.232

Low

810755

VPS71
Vacuolar protein sorting-associated protein 71

1

0

High-throughput

0.232

Low

810760

YMJ0
Putative uncharacterized protein YML090W

1

0

High-throughput

0.232

Low

810766

RRG8
Required for respiratory growth protein 8, mitochondrial

1

0

High-throughput

0.232

Low

810776

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.232

Low

810785

THP3
Protein THP3

1

0

High-throughput

0.232

Low

810786

CFT2
Cleavage factor two protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025