HitPredict

Interactor 1: EYA3 (P97480)
Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3)
Gene: EYA3

Interactor 2: SIX1 (Q62231)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 510 Mm			1 284
+	Hs
		124604 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30
+	Hs
		1405016 EYA3_HUMAN (1-510): 0: 708: 86.72		SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48
+	Hs
		341573 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30
+	Hs
		97045 E9PLN6_HUMAN (4-510): 0: 677: 51.44		SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30
+	Hs
		1149418 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30
+	Hs
		124654 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48
+	Mm
		999800 EYA3_MOUSE (1-510): 0: 752: 100.00		SIX5_MOUSE (1-278): 1.03e-59: 203: 42.81
+	Mm
		1021848 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX1_MOUSE (1-284): 2.91e-97: 289: 100.00
+	Hs
		341684 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48
+	Hs
		97046 E9PLN6_HUMAN (4-510): 0: 677: 51.44		SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48
+	Hs
		1405003 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48
+	Hs
		124662 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36
+	Hs
		341699 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36
+	Hs
		1405004 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36
+	Mm
		147613 EYA2_MOUSE (17-510): 0: 668: 46.13		SIX4_MOUSE (5-273): 1.6e-74: 244: 50.56
+	Mm
		1021847 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX4_MOUSE (5-273): 1.6e-74: 244: 50.56
+	Hs
		1323269 EYA3_HUMAN (1-510): 0: 708: 86.72		SIX5_HUMAN (2-262): 2.18e-58: 200: 43.89
+	Hs
		341621 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX5_HUMAN (2-262): 2.18e-58: 200: 43.89
+	Hs
		1323268 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX5_HUMAN (2-262): 2.18e-58: 200: 43.89
+	Mm
		999801 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX5_MOUSE (1-278): 1.03e-59: 203: 42.81