Protein: SIX1
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)

Gene: SIX1
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q15475

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

124604

EYA2
Protein phosphatase EYA2

7

20

Small-scale

0.962

High

1149418

EYA1
Protein phosphatase EYA1

6

20

Small-scale

0.952

High

341573

EYA4
Protein phosphatase EYA4

5

20

High-throughput

0.915

High

1007925

PO6F2
POU domain, class 6, transcription factor 2

2

13

High-throughput

0.783

High

1061705

TLE5
TLE family member 5

4

20

High-throughput

0.709

High

535938

MYH3
Myosin-3

3

3

High-throughput

0.667

High

556927

MYH7
Myosin-7

3

3

High-throughput

0.667

High

1149422

MYH4
Myosin-4

3

3

High-throughput

0.667

High

280919

HYPM
Huntingtin-interacting protein M

3

0

High-throughput

0.636

High

1149411

ERC6L
DNA excision repair protein ERCC-6-like

2

6

High-throughput

0.628

High

1047977

TLE3
Transducin-like enhancer protein 3

2

20

High-throughput

0.606

High

1048860

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.606

High

1149419

MDFI
MyoD family inhibitor

1

1

High-throughput

0.582

High

1149412

PKHG4
Puratrophin-1

2

0

High-throughput

0.580

High

97045

E9PLN6
Eyes absent homolog

1

20

High-throughput

0.575

High

1149410

CC85B
Coiled-coil domain-containing protein 85B

1

2

High-throughput

0.541

High

74499

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

133115

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

945702

FOXL2
Forkhead box protein L2

1

20

High-throughput

0.536

High

1130051

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.536

High

721718

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

1149416

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

317179

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

532605

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

535098

BIP
Endoplasmic reticulum chaperone BiP

1

1

Small-scale

0.479

High

801329

HSPA9
Stress-70 protein, mitochondrial

1

3

Small-scale

0.479

High

828214

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.479

High

869041

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

1149417

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1149420

FZR1
Fizzy-related protein homolog

1

2

Small-scale

0.479

High

468400

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.458

High

555398

SKI
Ski oncogene

1

0

Small-scale

0.458

High

1149421

FBX7
F-box only protein 7

1

0

Small-scale

0.458

High

482904

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.437

High

505164

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

813098

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

1149413

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.279

Low

1149415

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

1149414

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.269

Low

399576

VTNC
Vitronectin

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025