Protein: SIX4
Homeobox protein SIX4 (Sine oculis homeobox homolog 4)

Gene: SIX4
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q9UIU6

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341699

EYA4
Protein phosphatase EYA4

2

20

High-throughput

0.789

High

124662

EYA2
Protein phosphatase EYA2

2

20

Small-scale

0.757

High

1405004

EYA1
Protein phosphatase EYA1

1

20

High-throughput

0.691

High

181576

TBXT
T-box transcription factor T

1

12

High-throughput

0.618

High

549356

SRF
Serum response factor

1

3

High-throughput

0.618

High

662294

PAX7
Paired box protein Pax-7

1

19

High-throughput

0.618

High

685381

PAX6
Paired box protein Pax-6

1

15

High-throughput

0.618

High

725335

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.618

High

1458643

LHX3
LIM/homeobox protein Lhx3

1

9

High-throughput

0.618

High

1392949

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

474357

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

872856

SOX2
Transcription factor SOX-2

2

19

Small-scale

0.584

High

1088085

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1133722

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

397170

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

74638

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

430481

JUN
Transcription factor Jun

1

3

High-throughput

0.536

High

1383887

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1446165

CABP2
Calcium-binding protein 2

1

0

High-throughput

0.513

High

706344

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1402734

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

143313

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

194626

KDM6A
Lysine-specific demethylase 6A

1

4

Small-scale

0.479

High

240011

SOX15
Transcription factor SOX-15

1

18

High-throughput

0.479

High

538486

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

662514

GATA2
Endothelial transcription factor GATA-2

1

7

High-throughput

0.479

High

662670

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

7

High-throughput

0.479

High

775928

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

980506

H4
Histone H4

1

2

High-throughput

0.479

High

1091371

FOXL1
Forkhead box protein L1

1

18

High-throughput

0.479

High

1351189

SP7
Transcription factor Sp7

1

6

High-throughput

0.479

High

1367532

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1401435

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

1405452

FEV
Protein FEV

1

4

High-throughput

0.479

High

1458818

ZMYM2
Zinc finger MYM-type protein 2

1

3

High-throughput

0.479

High

976014

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

986799

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1097620

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1364004

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

231651

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.407

High

1332286

GG6L2
Golgin subfamily A member 6-like protein 2

1

7

High-throughput

0.407

High

1390923

LRC46
Leucine-rich repeat-containing protein 46

3

0

High-throughput

0.347

High


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Last updated: 11Aug2025