Protein: SIX5
Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)

Gene: SIX5
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q8N196

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002088 - lens development in camera-type eye

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1323269

EYA3
Protein phosphatase EYA3

2

20

Small-scale

0.789

High

341621

EYA4
Protein phosphatase EYA4

1

20

High-throughput

0.691

High

1323268

EYA1
Protein phosphatase EYA1

1

20

High-throughput

0.691

High

549339

SRF
Serum response factor

1

3

High-throughput

0.618

High

927407

ATX1
Ataxin-1

1

0

High-throughput

0.549

High

187134

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

284335

GEMI
Geminin

1

1

High-throughput

0.536

High

1091317

FOXL1
Forkhead box protein L1

1

16

High-throughput

0.536

High

1123039

FHL2
Four and a half LIM domains protein 2

1

5

High-throughput

0.536

High

1323262

STK40
Serine/threonine-protein kinase 40

1

1

High-throughput

0.536

High

1323263

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.536

High

1323266

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

High-throughput

0.536

High

1323271

FOXB1
Forkhead box protein B1

1

17

High-throughput

0.536

High

1323274

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

1

High-throughput

0.536

High

1323275

DICER
Endoribonuclease Dicer

1

2

High-throughput

0.536

High

1144068

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1272644

DET1
DET1 homolog

1

0

High-throughput

0.513

High

1323265

ARK2N
Protein ARK2N

1

0

High-throughput

0.513

High

1323272

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

1323273

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.513

High

1311337

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.489

High

1323267

TCPQM
T-complex protein 1 subunit theta-like 2

1

5

High-throughput

0.489

High

143113

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

474120

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

1087864

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1133529

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1323264

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.479

High

1323270

FEV
Protein FEV

1

8

High-throughput

0.479

High

231603

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.445

High


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Last updated: 11Aug2025