Protein: SIX2
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)

Gene: SIX2
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q9NPC8

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001822 - kidney development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1405003

EYA1
Protein phosphatase EYA1

3

20

High-throughput

0.871

High

341684

EYA4
Protein phosphatase EYA4

3

20

High-throughput

0.861

High

124654

EYA2
Protein phosphatase EYA2

2

20

High-throughput

0.811

High

1405016

EYA3
Protein phosphatase EYA3

2

20

High-throughput

0.811

High

1048103

TLE3
Transducin-like enhancer protein 3

4

20

High-throughput

0.698

High

221887

CHM2A
Charged multivesicular body protein 2a

2

2

High-throughput

0.628

High

274244

ANR17
Ankyrin repeat domain-containing protein 17

2

3

High-throughput

0.628

High

1134396

IMB1
Importin subunit beta-1

2

1

High-throughput

0.628

High

1061887

TLE5
TLE family member 5

2

20

High-throughput

0.606

High

1143097

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.602

High

1413177

PSMG3
Proteasome assembly chaperone 3

2

0

High-throughput

0.602

High

1325039

CLIP4
CAP-Gly domain-containing linker protein 4

2

0

High-throughput

0.580

High

97046

E9PLN6
Eyes absent homolog

1

20

High-throughput

0.575

High

1179254

ERC6L
DNA excision repair protein ERCC-6-like

2

12

High-throughput

0.574

High

1311411

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

3

High-throughput

0.574

High

1439642

CHM1A
Charged multivesicular body protein 1a

2

2

High-throughput

0.574

High

1446186

CHMP3
Charged multivesicular body protein 3

2

2

High-throughput

0.574

High

842870

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

12

High-throughput

0.541

High

1428929

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

1446188

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

1045801

TF65
Transcription factor p65

1

6

Small-scale

0.506

High

1270535

MARK2
Serine/threonine-protein kinase MARK2

1

1

High-throughput

0.489

High

980374

H4
Histone H4

1

2

High-throughput

0.479

High

1030039

RELB
Transcription factor RelB

1

6

Small-scale

0.479

High

1047870

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

423243

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.457

High

1212331

Q5T3G3
TLE family member 1, transcriptional corepressor

1

20

High-throughput

0.445

High

1279474

BN3D2
RNA 5'-monophosphate methyltransferase

2

0

High-throughput

0.328

High

1315354

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.328

High

1446187

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025