Protein: EYA3
Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3)

Gene: EYA3
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q99504

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1405016

SIX2
Homeobox protein SIX2

2

20

High-throughput

0.811

High

1323269

SIX5
Homeobox protein SIX5

2

20

Small-scale

0.789

High

1123088

FHL2
Four and a half LIM domains protein 2

3

1

High-throughput

0.656

High

1143852

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

565691

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.630

High

1405007

EYA3
Protein phosphatase EYA3

1

5

High-throughput

0.618

High

855737

CRK
Adapter molecule crk

2

2

High-throughput

0.594

High

1383824

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

591805

H2AX
Histone H2AX

1

1

Small-scale

0.515

High

246112

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

451250

NFL
Neurofilament light polypeptide

1

1

High-throughput

0.515

High

532892

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

686644

ELAV4
ELAV-like protein 4

1

0

High-throughput

0.511

High

326977

UBE4B
Ubiquitin conjugation factor E4 B

1

0

High-throughput

0.493

High

301652

WFS1
Wolframin

1

0

High-throughput

0.493

High

593784

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

843903

HD
Huntingtin

1

0

High-throughput

0.493

High

896867

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

905064

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.493

High

1369618

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1405019

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

143211

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

242688

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

325996

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.479

High

467590

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

474233

NFIC
Nuclear factor 1 C-type

1

8

High-throughput

0.479

High

584796

NDKA
Nucleoside diphosphate kinase A

1

1

High-throughput

0.479

High

610449

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

714376

PML
Protein PML

1

1

High-throughput

0.479

High

725309

TLX1
T-cell leukemia homeobox protein 1

1

4

High-throughput

0.479

High

731557

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

887157

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.479

High

998721

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017150

H33
Histone H3.3

1

1

High-throughput

0.479

High

1033174

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

1048074

TLE3
Transducin-like enhancer protein 3

1

6

High-throughput

0.479

High

1087969

NFIA
Nuclear factor 1 A-type

1

8

High-throughput

0.479

High

1094964

TRAF3
TNF receptor-associated factor 3

1

2

High-throughput

0.479

High

1112417

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

1

High-throughput

0.479

High

1112449

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

High-throughput

0.479

High

1133626

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.479

High

1351137

SP7
Transcription factor Sp7

1

1

High-throughput

0.479

High

1367096

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1387516

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

1405013

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1405014

GRPE1
GrpE protein homolog 1, mitochondrial

1

1

High-throughput

0.479

High

1405018

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

138284

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

407882

SEMG1
Semenogelin-1

1

0

High-throughput

0.458

High

414473

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

555418

SKI
Ski oncogene

1

0

Small-scale

0.458

High

628835

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

633777

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.458

High

907549

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

935038

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

975491

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.458

High

986660

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1219330

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

High-throughput

0.458

High

1276691

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1280429

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1334810

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1353556

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.458

High

1402240

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.458

High

1404560

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

1405008

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

High-throughput

0.458

High

1405011

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1405015

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1405017

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

318050

TOM70
Mitochondrial import receptor subunit TOM70

1

2

High-throughput

0.437

High

660496

ANFC
C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]

1

1

High-throughput

0.437

High

773966

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.437

High

1310583

CC28A
Coiled-coil domain-containing protein 28A

1

1

High-throughput

0.437

High

1405010

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

1

High-throughput

0.437

High

1209549

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1405020

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.305

High

249190

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1307620

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

347273

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

47405

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

943118

STX17
Syntaxin-17

1

0

High-throughput

0.249

Low

1405009

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.249

Low

1405012

T126A
Transmembrane protein 126A

1

0

High-throughput

0.249

Low

947039

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025