HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	9774977, 32445435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 1374
+	Hs
		1020888 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Mm
		192185 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		M3K5_MOUSE (1-1372): 0: 1451: 94.13
+	Hs
		1305607 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		129590 TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		1024746 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		1305587 TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		1023648 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		STK3_HUMAN (686-1116): 1.95e-98: 326: 25.39
+	Hs
		850645 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		KS6A3_HUMAN (623-1074): 1.34e-117: 387: 19.83
+	Mm
		578260 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		KS6A3_MOUSE (623-1074): 9.86e-118: 387: 19.83
+	Hs
		1023147 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		STK4_HUMAN (686-954): 1.73e-97: 323: 33.95
+	Hs
		1020637 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		1306410 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		M3K3_HUMAN (685-940): 1.87e-43: 171: 40.08
+	Mm
		936233 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		M3K3_MOUSE (685-940): 1.03e-43: 171: 40.08
+	Hs
		682088 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Mm
		682105 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		AKT1_MOUSE (438-615): 2e-25: 113: 14.14
+	Mm
		139644 TRAF4_MOUSE (27-136): 4.84e-09: 59.9: 18.75		M3K4_MOUSE (686-945): 2.46e-41: 169: 40.45
+	Hs
		682006 TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64