HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: SPDE1 (Q8NFV5)
Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
Gene: SPDYE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15574121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 336
+	Hs
		667938 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		SPDE1_HUMAN (1-336): 0: 545: 100.00
+	Hs
		443448 CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01		SPDE1_HUMAN (1-336): 0: 545: 100.00
+	Hs
		667901 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		1025469 CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		667900 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		SPDYC_HUMAN (153-332): 1.1e-53: 179: 32.60
+	Hs
		443399 CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Xl
		772466 CDK1A_XENLA (1-289): 8.14e-133: 380: 56.01		SPD1A_XENLA (119-332): 5.96e-60: 196: 33.95
+	Xl
		663812 CDK1B_XENLA (1-289): 1.25e-131: 376: 55.33		SPD1A_XENLA (119-332): 5.96e-60: 196: 33.95
+	Hs
		443398 CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01		SPDYC_HUMAN (153-332): 1.1e-53: 179: 32.60
+	Hs
		1025553 CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		66868 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		66882 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		667892 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		SPDE7_HUMAN (33-110): 1.47e-21: 92.6: 53.66
+	Hs
		66883 CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		66863 CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		443391 CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01		SPDE7_HUMAN (33-110): 1.47e-21: 92.6: 53.66
+	Hs
		66884 CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84