HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: SPDE1 (Q8NFV5)
Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
Gene: SPDYE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15574121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 336
+	Hs
		443448 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		SPDE1_HUMAN (1-336): 0: 545: 100.00
+	Hs
		1025489 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		SPDE1_HUMAN (1-336): 0: 545: 100.00
+	Hs
		667901 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		667900 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		SPDYC_HUMAN (153-332): 1.1e-53: 179: 32.60
+	Hs
		443399 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Xl
		772466 CDK1A_XENLA (1-291): 3.46e-143: 406: 67.12		SPD1A_XENLA (119-332): 5.96e-60: 196: 33.95
+	Xl
		663812 CDK1B_XENLA (1-291): 2.92e-142: 404: 66.78		SPD1A_XENLA (119-332): 5.96e-60: 196: 33.95
+	Hs
		1025469 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		443398 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		SPDYC_HUMAN (153-332): 1.1e-53: 179: 32.60
+	Hs
		66868 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		667892 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		SPDE7_HUMAN (33-110): 1.47e-21: 92.6: 53.66
+	Hs
		66882 CDK3_HUMAN (1-294): 4.77e-154: 434: 76.87		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		1025553 CDK16_HUMAN (1-286): 4.12e-107: 322: 55.40		SPDYA_HUMAN (116-333): 7.51e-61: 198: 28.38
+	Hs
		66863 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		443391 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		SPDE7_HUMAN (33-110): 1.47e-21: 92.6: 53.66
+	Hs
		66883 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84
+	Hs
		66884 CDK16_HUMAN (1-286): 4.12e-107: 322: 55.40		SPDE4_HUMAN (13-110): 1.78e-23: 98.8: 57.84