HitPredict

Interactor 1: VIME (P08670)
Vimentin
Gene: VIM

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	26496610, 28514442, 30021884, 34079125, 33961781, 35271311, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005737 - cytoplasm GO:0005882 - intermediate filament GO:0045111 - intermediate filament cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 466 Hs			1 1621
+	Hs
		409029 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		NEST_HUMAN (1-1621): 1.09e-115: 404: 100.00
+	Hs
		569060 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		NEST_HUMAN (1-1621): 1.09e-115: 404: 100.00
+	Hs
		408979 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		443316 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		409072 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		K1H2_HUMAN (6-313): 1.75e-82: 281: 20.63
+	Hs
		280770 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		318775 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		K2C75_HUMAN (6-319): 4.7e-60: 219: 21.43
+	Hs
		408987 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		MYH1_HUMAN (549-1583): 5.34e-33: 142: 10.34
+	Hs
		408991 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35
+	Hs
		535322 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35
+	Hs
		166094 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		SYNEM_HUMAN (6-311): 3.29e-17: 90.5: 33.97
+	Hs
		422142 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		NFL_HUMAN (7-323): 1.31e-18: 93.6: 27.95
+	Hs
		409089 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		AINX_HUMAN (8-317): 2.29e-17: 89.4: 27.59
+	Hs
		166100 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		SYNEM_HUMAN (6-311): 3.29e-17: 90.5: 33.97
+	Hs
		569086 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		AINX_HUMAN (8-317): 2.29e-17: 89.4: 27.59
+	Hs
		409022 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		PERI_HUMAN (8-343): 9.5e-15: 80.9: 27.87
+	Hs
		408975 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		NFM_HUMAN (8-333): 4.76e-14: 79.7: 26.21
+	Hs
		569056 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		PERI_HUMAN (8-343): 9.5e-15: 80.9: 27.87
+	Hs
		422344 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		NFM_HUMAN (8-333): 4.76e-14: 79.7: 26.21
+	Hs
		569045 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		DESM_HUMAN (8-316): 2.1e-14: 79.7: 25.47