HitPredict

Interactor 1: SPDE4 (A6NLX3)
Speedy protein E4
Gene: SPDYE4

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.80	0.640

Property	Details
Experiments	35016035
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 237 Hs			1 298
+	Hs
		66882 SPDE4_HUMAN (1-237): 1.22e-121: 347: 100.00		CDK3_HUMAN (1-294): 4.77e-154: 434: 76.87
+	Hs
		667892 SPDE7_HUMAN (55-237): 7.71e-103: 298: 66.35		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Hs
		66863 SPDE4_HUMAN (1-237): 1.22e-121: 347: 100.00		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		66883 SPDE4_HUMAN (1-237): 1.22e-121: 347: 100.00		CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39
+	Hs
		443391 SPDE7_HUMAN (55-237): 7.71e-103: 298: 66.35		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		667901 SPDYA_HUMAN (67-235): 1.06e-78: 240: 35.84		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Hs
		667900 SPDYC_HUMAN (104-233): 1.23e-65: 206: 45.80		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Hs
		66884 SPDE4_HUMAN (1-237): 1.22e-121: 347: 100.00		CDK16_HUMAN (1-286): 4.12e-107: 322: 55.40
+	Hs
		443399 SPDYA_HUMAN (67-235): 1.06e-78: 240: 35.84		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Xl
		772466 SPD1A_XENLA (70-235): 4.15e-74: 228: 41.32		CDK1A_XENLA (1-291): 3.46e-143: 406: 67.12
+	Hs
		1025469 SPDYA_HUMAN (67-235): 1.06e-78: 240: 35.84		CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39
+	Xl
		663812 SPD1A_XENLA (70-235): 4.15e-74: 228: 41.32		CDK1B_XENLA (1-291): 2.92e-142: 404: 66.78
+	Hs
		443398 SPDYC_HUMAN (104-233): 1.23e-65: 206: 45.80		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		1025553 SPDYA_HUMAN (67-235): 1.06e-78: 240: 35.84		CDK16_HUMAN (1-286): 4.12e-107: 322: 55.40
+	Hs
		667938 SPDE1_HUMAN (36-113): 1.82e-16: 79: 62.82		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Hs
		443448 SPDE1_HUMAN (36-113): 1.82e-16: 79: 62.82		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		1025489 SPDE1_HUMAN (36-113): 1.82e-16: 79: 62.82		CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39