HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: DDX21 (Q9NR30)
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
Gene: DDX21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 20020773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005739 - mitochondrion
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 783
+	Hs
		162169 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		DDX21_HUMAN (1-783): 0: 543: 100.00
+	Hs
		852185 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		DDX21_HUMAN (1-783): 0: 543: 100.00
+	Hs
		1025931 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		DDX50_HUMAN (49-728): 1.52e-137: 425: 59.12
+	Hs
		1025882 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		DDX17_HUMAN (122-628): 1.38e-136: 423: 24.46
+	Hs
		134014 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		DDX3X_HUMAN (5-575): 3.96e-137: 422: 23.55
+	Hs
		571426 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		DDX5_HUMAN (92-620): 4.08e-135: 415: 24.81
+	Mm
		1207264 TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14		Q8BTS0_MOUSE (92-620): 1.47e-135: 416: 24.81
+	Hs
		516711 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		DDX21_HUMAN (1-783): 0: 543: 100.00
+	Hs
		161959 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		DDX5_HUMAN (92-620): 4.08e-135: 415: 24.81
+	Hs
		571368 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		DDX5_HUMAN (92-620): 4.08e-135: 415: 24.81
+	Hs
		1048249 HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93		DDX21_HUMAN (1-783): 0: 543: 100.00
+	Hs
		134018 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		DDX3X_HUMAN (5-575): 3.96e-137: 422: 23.55
+	Mm
		857323 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		DDX17_MOUSE (122-628): 3.34e-135: 417: 24.46
+	Mm
		857351 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		Q8BTS0_MOUSE (92-620): 1.47e-135: 416: 24.81
+	Hs
		133858 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		DDX3X_HUMAN (5-575): 3.96e-137: 422: 23.55
+	Hs
		1048159 HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93		DDX17_HUMAN (122-628): 1.38e-136: 423: 24.46
+	Sc
		376580 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		DED1_YEAST (196-541): 2.98e-56: 205: 37.98
+	Hs
		516391 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		IF4A3_HUMAN (169-554): 5.06e-54: 194: 32.23