Protein: IKBB
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)

Gene: IKBB, NFKBIB
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q15653

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006351 - DNA-templated transcription
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1045325

TF65
Transcription factor p65

18

20

Small-scale

0.989

High

1048861

REL
Proto-oncogene c-Rel

10

20

Small-scale

0.971

High

626242

NFKB1
Nuclear factor NF-kappa-B p105 subunit

8

20

High-throughput

0.968

High

1151502

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

8

18

Small-scale

0.962

High

167902

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

6

20

Small-scale

0.947

High

177877

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

6

20

Small-scale

0.940

High

683461

IKBA
NF-kappa-B inhibitor alpha

5

17

Small-scale

0.931

High

1026726

NFKB2
Nuclear factor NF-kappa-B p100 subunit

5

18

High-throughput

0.919

High

1151511

NEMO
NF-kappa-B essential modulator

5

20

Small-scale

0.912

High

1151508

FBW1A
F-box/WD repeat-containing protein 1A

4

20

Small-scale

0.875

High

1151497

BTBD6
BTB/POZ domain-containing protein 6

2

1

High-throughput

0.783

High

1151506

FBW1B
F-box/WD repeat-containing protein 11

2

20

High-throughput

0.737

High

997736

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.724

High

659487

CRCM
Colorectal mutant cancer protein

5

4

High-throughput

0.714

High

334561

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

5

Small-scale

0.713

High

628790

TBP
TATA-box-binding protein

4

2

High-throughput

0.694

High

290317

KS6A4
Ribosomal protein S6 kinase alpha-4

1

7

High-throughput

0.691

High

1029998

RELB
Transcription factor RelB

1

20

High-throughput

0.691

High

1151488

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

11

High-throughput

0.691

High

1151489

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

20

High-throughput

0.691

High

1151493

BIRC7
Baculoviral IAP repeat-containing protein 7

3

8

High-throughput

0.667

High

1151471

BAK
Bcl-2 homologous antagonist/killer

1

4

Small-scale

0.647

High

363329

EGFR
Epidermal growth factor receptor

1

17

High-throughput

0.646

High

1122396

GIT2
ARF GTPase-activating protein GIT2

1

18

High-throughput

0.625

High

1116477

FHL3
Four and a half LIM domains protein 3

1

8

High-throughput

0.621

High

1151495

TONSL
Tonsoku-like protein

1

19

High-throughput

0.618

High

457460

TBB5
Tubulin beta chain

1

16

High-throughput

0.618

High

910919

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.618

High

934657

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.618

High

992189

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.618

High

1112504

CUL1
Cullin-1

1

20

High-throughput

0.618

High

1151469

IKBB
NF-kappa-B inhibitor beta

1

17

High-throughput

0.618

High

1151478

TBA1A
Tubulin alpha-1A chain

1

15

High-throughput

0.618

High

1151479

BRAP
BRCA1-associated protein

1

9

Small-scale

0.618

High

1151487

KI18A
Kinesin-like protein KIF18A

1

5

High-throughput

0.618

High

1151503

KBRS1
NF-kappa-B inhibitor-interacting Ras-like protein 1

1

17

Small-scale

0.618

High

1151505

NGAP
Ras GTPase-activating protein nGAP

2

11

High-throughput

0.611

High

1151483

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

0

High-throughput

0.601

High

963181

LYSC
Lysozyme C

1

0

High-throughput

0.586

High

1151494

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

Small-scale

0.578

High

719146

MPIP1
M-phase inducer phosphatase 1

1

1

High-throughput

0.541

High

161721

APAF
Apoptotic protease-activating factor 1

1

6

High-throughput

0.536

High

298598

RAD17
Cell cycle checkpoint protein RAD17

1

2

High-throughput

0.536

High

1151472

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

2

High-throughput

0.536

High

1151476

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

1

High-throughput

0.536

High

1151498

TGS1
Trimethylguanosine synthase

1

1

High-throughput

0.536

High

625822

RXRA
Retinoic acid receptor RXR-alpha

1

15

Small-scale

0.527

High

1151480

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

3

High-throughput

0.515

High

187518

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

1137219

CND1
Condensin complex subunit 1

1

0

High-throughput

0.513

High

1151491

SYMPK
Symplekin

1

0

High-throughput

0.513

High

1151496

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

422153

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

789506

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.501

High

1151490

ESR2
Estrogen receptor beta

1

20

Small-scale

0.501

High

1151510

NCOR2
Nuclear receptor corepressor 2

1

15

Small-scale

0.501

High

1151485

BANP
Protein BANP

1

1

High-throughput

0.489

High

74029

MYO9A
Unconventional myosin-IXa

1

10

High-throughput

0.479

High

172848

XPO1
Exportin-1

1

16

High-throughput

0.479

High

180293

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

190923

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

252968

PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

1

3

Small-scale

0.479

High

347046

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.479

High

347716

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

404081

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

424202

S10A8
Protein S100-A8

1

2

High-throughput

0.479

High

460540

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

461511

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.479

High

468404

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.479

High

507200

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

High-throughput

0.479

High

535100

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

537214

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

587674

DESP
Desmoplakin

1

20

High-throughput

0.479

High

612652

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

620384

NUCL
Nucleolin

1

5

High-throughput

0.479

High

655211

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

High-throughput

0.479

High

761408

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

834455

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

841751

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

862854

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

11

High-throughput

0.479

High

910528

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

7

High-throughput

0.479

High

984419

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.479

High

985681

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

993188

ACTG
Actin, cytoplasmic 2

1

12

High-throughput

0.479

High

1026050

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.479

High

1027480

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

9

High-throughput

0.479

High

1111448

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

15

High-throughput

0.479

High

1151474

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.479

High

1151482

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.479

High

1151492

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.479

High

1151499

Q9BSR4
DNA-directed RNA polymerase

1

2

High-throughput

0.479

High

1151501

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

2

High-throughput

0.479

High

611886

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

912064

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

983659

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1151470

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.458

High

1151477

TBPL2
TATA box-binding protein-like 2

1

2

High-throughput

0.445

High

339984

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

1

High-throughput

0.437

High

516842

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.437

High

801330

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.437

High

856270

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.437

High

1151473

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

4

High-throughput

0.437

High

1151486

RLA0L
Putative ribosomal protein uL10-like

1

1

High-throughput

0.437

High

1151504

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.437

High

1151507

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.437

High

1151509

SRPRB
Signal recognition particle receptor subunit beta

1

6

High-throughput

0.437

High

1151484

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.407

High

1151500

RPA49
DNA-directed RNA polymerase I subunit RPA49

4

0

High-throughput

0.362

High

605459

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

252557

TSN1
Tetraspanin-1

1

0

High-throughput

0.282

High

1151475

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

399409

SLPI
Antileukoproteinase

1

0

High-throughput

0.249

Low

1151481

CC28A
Coiled-coil domain-containing protein 28A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025