Protein: IKBE
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)

Gene: IKBE, NFKBIE
Organism: Homo sapiens
Interactions: 67
UniProt ID: O00221

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0140311 - protein sequestering activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127780

TF65
Transcription factor p65

9

20

Small-scale

0.975

High

127781

REL
Proto-oncogene c-Rel

9

20

Small-scale

0.974

High

127761

NFKB1
Nuclear factor NF-kappa-B p105 subunit

5

19

Small-scale

0.931

High

127779

RELB
Transcription factor RelB

4

20

High-throughput

0.895

High

127778

NFKB2
Nuclear factor NF-kappa-B p100 subunit

3

19

Small-scale

0.860

High

127787

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

15

High-throughput

0.793

High

127789

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.698

High

127763

IKBA
NF-kappa-B inhibitor alpha

1

19

High-throughput

0.691

High

127760

PLAK
Junction plakoglobin

1

13

High-throughput

0.621

High

127738

IKBE
NF-kappa-B inhibitor epsilon

1

19

High-throughput

0.618

High

127740

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.618

High

127742

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

15

High-throughput

0.618

High

127743

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.618

High

127747

ANR17
Ankyrin repeat domain-containing protein 17

1

15

High-throughput

0.618

High

127750

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.618

High

127751

TBB5
Tubulin beta chain

1

20

High-throughput

0.618

High

127768

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.618

High

127771

TERA
Transitional endoplasmic reticulum ATPase

1

14

High-throughput

0.618

High

127775

SKP1
S-phase kinase-associated protein 1

1

6

High-throughput

0.618

High

127776

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.618

High

127783

CUL1
Cullin-1

1

20

High-throughput

0.618

High

127791

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

9

High-throughput

0.618

High

127792

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

20

High-throughput

0.618

High

127796

FBW1B
F-box/WD repeat-containing protein 11

1

20

High-throughput

0.618

High

127801

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.618

High

127803

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.618

High

127741

XPO1
Exportin-1

2

20

Small-scale

0.584

High

127745

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

127746

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

19

Small-scale

0.584

High

127797

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

14

Small-scale

0.584

High

127782

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.561

High

127744

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

10

High-throughput

0.536

High

127748

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.536

High

127788

SKA3
Spindle and kinetochore-associated protein 3

1

1

High-throughput

0.536

High

127794

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

20

High-throughput

0.536

High

127772

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

127799

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.501

High

127802

NCOR2
Nuclear receptor corepressor 2

1

15

Small-scale

0.501

High

127755

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

127739

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

11

High-throughput

0.479

High

127749

BAG2
BAG family molecular chaperone regulator 2

1

7

High-throughput

0.479

High

127752

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

High-throughput

0.479

High

127753

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

127754

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

127757

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

127758

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

127759

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

127762

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

127764

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.479

High

127765

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

127766

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

127767

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

127769

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

127770

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

127773

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

127774

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

127777

CLH1
Clathrin heavy chain 1

1

6

High-throughput

0.479

High

127784

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

High-throughput

0.479

High

127785

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

15

High-throughput

0.479

High

127790

ARHG2
Rho guanine nucleotide exchange factor 2

1

8

High-throughput

0.479

High

127793

WWTR1
WW domain-containing transcription regulator protein 1

1

10

High-throughput

0.479

High

127795

HOOK1
Protein Hook homolog 1

1

13

High-throughput

0.479

High

127800

RUVB2
RuvB-like 2

1

9

High-throughput

0.479

High

127786

Q8IWG5
ANKHD1 protein

1

9

High-throughput

0.437

High

127798

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.437

High

127756

CB27B
Putative uncharacterized protein CDRT15P3

2

0

High-throughput

0.305

High


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Last updated: 11Aug2025