HitPredict

Interactor 1: GRM1 (Q13255)
Metabotropic glutamate receptor 1 (mGluR1)
Gene: GRM1

Interactor 2: GRM1 (Q13255)
Metabotropic glutamate receptor 1 (mGluR1)
Gene: GRM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 10945991, 10349865, 24603153
Identification Methods pull down, affinity chromatography technology, x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_3~7tm_3, 7tm_3~NCD3G, ANF_receptor~ANF_receptor, ANF_receptor~NCD3G, NCD3G~NCD3G
Common GO terms GO:0001640 - adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
and 20 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1194
Hs

1 1194
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024