Protein: CASP6
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]

Gene: CASP6
Organism: Homo sapiens
Interactions: 239
UniProt ID: P55212

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877008

CASP6
Caspase-6

8

17

Small-scale

0.969

High

877035

CASP8
Caspase-8

3

17

Small-scale

0.845

High

788171

CASP3
Caspase-3

2

18

Small-scale

0.841

High

877014

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.754

High

876935

CASP7
Caspase-7

1

19

Small-scale

0.692

High

877009

MTPN
Myotrophin

1

1

High-throughput

0.691

High

877112

CASPA
Caspase-10

1

17

Small-scale

0.647

High

790962

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

0

High-throughput

0.630

High

877020

GABP1
GA-binding protein subunit beta-1

1

0

High-throughput

0.630

High

496655

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.602

High

877010

IPKA
cAMP-dependent protein kinase inhibitor alpha

2

0

High-throughput

0.580

High

877103

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

877122

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

877174

IRAK3
Interleukin-1 receptor-associated kinase 3

1

1

Small-scale

0.561

High

877156

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

0

High-throughput

0.556

High

212376

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

3

High-throughput

0.541

High

877024

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.541

High

877175

NEMO
NF-kappa-B essential modulator

1

3

High-throughput

0.541

High

877162

PHF11
PHD finger protein 11

1

5

High-throughput

0.536

High

48049

E2F8
Transcription factor E2F8

1

1

High-throughput

0.515

High

124809

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.515

High

127916

EMAL1
Echinoderm microtubule-associated protein-like 1

1

5

High-throughput

0.515

High

182329

PER1
Period circadian protein homolog 1

1

3

High-throughput

0.515

High

207165

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.515

High

234688

DLX3
Homeobox protein DLX-3

1

1

High-throughput

0.515

High

238160

PLIN3
Perilipin-3

1

2

High-throughput

0.515

High

245461

SHOX2
Short stature homeobox protein 2

1

2

High-throughput

0.515

High

344284

AACT
Alpha-1-antichymotrypsin

1

6

High-throughput

0.515

High

346337

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.515

High

386391

P53
Cellular tumor antigen p53

1

5

High-throughput

0.515

High

451779

ANXA4
Annexin A4

1

1

High-throughput

0.515

High

473795

JMJD7
Bifunctional peptidase and

1

1

High-throughput

0.515

High

568963

CAN2
Calpain-2 catalytic subunit

1

2

High-throughput

0.515

High

595813

CAN3
Calpain-3

1

4

High-throughput

0.515

High

606959

SCP2
Sterol carrier protein 2

1

2

High-throughput

0.515

High

611224

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.515

High

624417

CCNC
Cyclin-C

1

2

High-throughput

0.515

High

653903

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

High-throughput

0.515

High

663968

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

1

High-throughput

0.515

High

716912

CTNB1
Catenin beta-1

1

2

High-throughput

0.515

High

734569

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.515

High

791420

HD
Huntingtin

1

4

High-throughput

0.515

High

822553

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

1

High-throughput

0.515

High

869587

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.515

High

877011

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.515

High

877015

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

1

High-throughput

0.515

High

877018

TF65
Transcription factor p65

1

2

High-throughput

0.515

High

877019

Q05CR2
ZNF248 protein

1

1

High-throughput

0.515

High

877021

RING1
E3 ubiquitin-protein ligase RING1

1

4

High-throughput

0.515

High

877022

PPARA
Peroxisome proliferator-activated receptor alpha

1

5

High-throughput

0.515

High

877025

TP53B
TP53-binding protein 1

1

3

High-throughput

0.515

High

877030

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.515

High

877036

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.515

High

877037

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.515

High

877042

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

5

High-throughput

0.515

High

877048

GLYR1
Cytokine-like nuclear factor N-PAC

1

3

High-throughput

0.515

High

877054

PKHG4
Puratrophin-1

1

2

High-throughput

0.515

High

877058

AKCL1
Putative aldo-keto reductase family 1 member C8

1

2

High-throughput

0.515

High

877065

LEG9C
Galectin-9C

1

2

High-throughput

0.515

High

877066

OTU7B
OTU domain-containing protein 7B

1

6

High-throughput

0.515

High

877069

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.515

High

877083

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

High-throughput

0.515

High

877095

RNF10
E3 ubiquitin-protein ligase RNF10

1

2

High-throughput

0.515

High

877101

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.515

High

877107

CHMP7
Charged multivesicular body protein 7

1

1

High-throughput

0.515

High

877109

JADE3
Protein Jade-3

1

2

High-throughput

0.515

High

877110

DPF1
Zinc finger protein neuro-d4

1

5

High-throughput

0.515

High

877115

SPSB1
SPRY domain-containing SOCS box protein 1

1

6

High-throughput

0.515

High

877116

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.515

High

877119

HBAP1
HSPB1-associated protein 1

1

2

High-throughput

0.515

High

877125

ZN597
Zinc finger protein 597

1

3

High-throughput

0.515

High

877127

BTBD9
BTB/POZ domain-containing protein 9

1

4

High-throughput

0.515

High

877132

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.515

High

877133

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.515

High

877141

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

1

High-throughput

0.515

High

877151

SHLB2
Endophilin-B2

1

2

High-throughput

0.515

High

877152

HELLS
Lymphoid-specific helicase

1

5

High-throughput

0.515

High

877153

FGF21
Fibroblast growth factor 21

1

1

High-throughput

0.515

High

877154

BRWD1
Bromodomain and WD repeat-containing protein 1

1

5

High-throughput

0.515

High

877160

KLHL3
Kelch-like protein 3

1

3

High-throughput

0.515

High

877165

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.515

High

877173

ACL7B
Actin-like protein 7B

1

7

High-throughput

0.515

High

877139

GBP3
Guanylate-binding protein 3

1

0

High-throughput

0.513

High

877148

IL26
Interleukin-26

1

0

High-throughput

0.513

High

877041

MK06
Mitogen-activated protein kinase 6

1

8

High-throughput

0.508

High

394412

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.501

High

414224

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

435023

SP1
Transcription factor Sp1

1

2

Small-scale

0.501

High

877013

NUCB2
Nucleobindin-2

1

5

Small-scale

0.501

High

877026

TRAF1
TNF receptor-associated factor 1

1

18

Small-scale

0.501

High

877033

UBE4A
Ubiquitin conjugation factor E4 A

1

2

Small-scale

0.501

High

877051

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

1

Small-scale

0.501

High

877063

A16L1
Autophagy-related protein 16-1

1

3

Small-scale

0.501

High

877078

CSN6
COP9 signalosome complex subunit 6

1

5

Small-scale

0.501

High

877106

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.501

High

877118

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.501

High

877168

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.501

High

877016

SATB1
DNA-binding protein SATB1

1

0

Small-scale

0.493

High

2016

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.493

High

123210

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.493

High

130152

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.493

High

135849

WNT7A
Protein Wnt-7a

1

0

High-throughput

0.493

High

174284

TELT
Telethonin

1

0

High-throughput

0.493

High

215879

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.493

High

235771

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

246076

PP1RB
E3 ubiquitin-protein ligase PPP1R11

1

0

High-throughput

0.493

High

416896

APOA4
Apolipoprotein A-IV

1

0

High-throughput

0.493

High

451405

CLCA
Clathrin light chain A

1

0

High-throughput

0.493

High

579250

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.493

High

714611

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.493

High

737080

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.493

High

738834

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.493

High

742164

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

828966

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.493

High

870993

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.493

High

871851

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.493

High

877012

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.493

High

877023

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.493

High

877027

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.493

High

877029

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.493

High

877031

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.493

High

877032

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.493

High

877034

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

877038

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.493

High

877040

LPAL2
Putative apolipoprotein(a)-like protein 2

1

0

High-throughput

0.493

High

877055

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.493

High

877057

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.493

High

877062

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.493

High

877064

ADAL
Adenosine deaminase-like protein

1

0

High-throughput

0.493

High

877070

H3C
Histone H3.3C

1

0

High-throughput

0.493

High

877072

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.493

High

877076

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.493

High

877081

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.493

High

877084

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.493

High

877085

ARCH
Protein archease

1

0

High-throughput

0.493

High

877092

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.493

High

877094

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.493

High

877096

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.493

High

877100

PEPL1
Probable aminopeptidase NPEPL1

1

0

High-throughput

0.493

High

877102

NUP37
Nucleoporin Nup37

1

0

High-throughput

0.493

High

877111

SYMPK
Symplekin

1

0

High-throughput

0.493

High

877114

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.493

High

877120

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.493

High

877121

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.493

High

877124

ZN333
Zinc finger protein 333

1

0

High-throughput

0.493

High

877126

KAD8
Adenylate kinase 8

1

0

High-throughput

0.493

High

877128

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

0

High-throughput

0.493

High

877129

PCY2
Ethanolamine-phosphate cytidylyltransferase

1

0

High-throughput

0.493

High

877130

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.493

High

877131

DPYL5
Dihydropyrimidinase-related protein 5

1

0

High-throughput

0.493

High

877134

HAUS8
HAUS augmin-like complex subunit 8

1

0

High-throughput

0.493

High

877135

PHF23
PHD finger protein 23

1

0

High-throughput

0.493

High

877136

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.493

High

877137

SHP1L
Testicular spindle-associated protein SHCBP1L

1

0

High-throughput

0.493

High

877138

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.493

High

877140

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.493

High

877142

LHX5
LIM/homeobox protein Lhx5

1

0

High-throughput

0.493

High

877144

PAAT
ATPase PAAT

1

0

High-throughput

0.493

High

877145

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.493

High

877146

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.493

High

877147

CD209
CD209 antigen

1

0

High-throughput

0.493

High

877149

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

High-throughput

0.493

High

877150

FERY3
Ferry endosomal RAB5 effector complex subunit 3

1

0

High-throughput

0.493

High

877158

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.493

High

877164

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.493

High

877166

JUPI1
Jupiter microtubule associated homolog 1

1

0

High-throughput

0.493

High

877167

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

0

High-throughput

0.493

High

877169

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

1

0

High-throughput

0.493

High

877170

NAGA
N-acetylglucosamine-6-phosphate deacetylase

1

0

High-throughput

0.493

High

877171

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.493

High

877074

HACD2
Very-long-chain

1

1

High-throughput

0.489

High

877028

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.486

High

877039

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

226985

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

358993

CRYAB
Alpha-crystallin B chain

1

10

Small-scale

0.479

High

720079

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

877077

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

877172

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.479

High

46642

A0A384MDV8
Epididymis secretory sperm binding protein

1

7

High-throughput

0.470

High

81582

B7Z3E8
cDNA FLJ51208

1

2

High-throughput

0.470

High

646602

AOFB
Amine oxidase [flavin-containing] B

1

1

High-throughput

0.470

High

814002

RGR
RPE-retinal G protein-coupled receptor

1

1

High-throughput

0.470

High

877043

ZN829
Zinc finger protein 829

1

2

High-throughput

0.470

High

877047

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

1

High-throughput

0.470

High

877056

KRBX4
KRAB domain-containing protein 4

1

4

High-throughput

0.470

High

877073

ASCL4
Achaete-scute homolog 4

1

1

High-throughput

0.470

High

877090

KT222
Keratin-like protein KRT222

1

3

High-throughput

0.470

High

877093

KLH36
Kelch-like protein 36

1

3

High-throughput

0.470

High

877104

KLDC4
Kelch domain-containing protein 4

1

3

High-throughput

0.470

High

877123

LOXL4
Lysyl oxidase homolog 4

1

1

High-throughput

0.470

High

877161

TEFF2
Tomoregulin-2

1

2

High-throughput

0.470

High

877017

NUCB1
Nucleobindin-1

1

5

Small-scale

0.457

High

877163

RWD2A
RWD domain-containing protein 2A

1

0

High-throughput

0.279

Low

58541

MBPHL
Myosin-binding protein H-like

1

0

High-throughput

0.268

Low

63325

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.268

Low

168366

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.268

Low

303893

YIF1A
Protein YIF1A

1

0

High-throughput

0.268

Low

318473

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.268

Low

358602

CO2A1
Collagen alpha-1(II) chain

1

0

High-throughput

0.268

Low

413030

CHLE
Cholinesterase

1

0

High-throughput

0.268

Low

484248

LYNX1
Ly-6/neurotoxin-like protein 1

1

0

High-throughput

0.268

Low

484441

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.268

Low

527372

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

645962

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.268

Low

782113

PTGDS
Prostaglandin-H2 D-isomerase

1

0

High-throughput

0.268

Low

877044

CMA1D
Protein CIMAP1D

1

0

High-throughput

0.268

Low

877045

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.268

Low

877046

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

877049

F135B
Protein FAM135B

1

0

High-throughput

0.268

Low

877050

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

877052

Q53NU3
cDNA, FLJ92284

1

0

High-throughput

0.268

Low

877053

CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1

1

0

High-throughput

0.268

Low

877059

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.268

Low

877060

EF1DL
Putative elongation factor 1-delta-like protein

1

0

High-throughput

0.268

Low

877061

RUAS1
Putative uncharacterized protein RUSC1-AS1

1

0

High-throughput

0.268

Low

877067

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.268

Low

877068

OGFD2
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

1

0

High-throughput

0.268

Low

877071

CNST
Consortin

1

0

High-throughput

0.268

Low

877075

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

877079

NUP54
Nucleoporin p54

1

0

High-throughput

0.268

Low

877080

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

877082

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

877086

LRC56
Leucine-rich repeat-containing protein 56

1

0

High-throughput

0.268

Low

877087

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

877088

CF218
Putative uncharacterized protein encoded by LINC00518

1

0

High-throughput

0.268

Low

877089

F177A
Protein FAM177A1

1

0

High-throughput

0.268

Low

877091

CD033
UPF0462 protein C4orf33

1

0

High-throughput

0.268

Low

877097

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.268

Low

877098

WDR31
WD repeat-containing protein 31

1

0

High-throughput

0.268

Low

877099

PRCA1
Protein PROCA1

1

0

High-throughput

0.268

Low

877105

RAB2B
Ras-related protein Rab-2B

1

0

High-throughput

0.268

Low

877108

ABEC4
Putative C->U-editing enzyme APOBEC-4

1

0

High-throughput

0.268

Low

877113

MAL2
Protein MAL2

1

0

High-throughput

0.268

Low

877117

MID49
Mitochondrial dynamics protein MID49

1

0

High-throughput

0.268

Low

877143

NAA60
N-alpha-acetyltransferase 60

1

0

High-throughput

0.268

Low

877155

SEM4G
Semaphorin-4G

1

0

High-throughput

0.268

Low

877157

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

877159

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024