Protein: NMDE3
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)

Gene: NMDE3, GRIN2C
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q14957

Gene Ontology (top 5):
GO:0004972 - NMDA glutamate receptor activity
GO:0005261 - monoatomic cation channel activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0007215 - glutamate receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1133905

DLG3
Disks large homolog 3

2

20

Small-scale

0.629

High

1051663

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

20

Small-scale

0.618

High

1133914

ERBIN
Erbin

2

4

Small-scale

0.613

High

1006065

DLG4
Disks large homolog 4

1

20

Small-scale

0.589

High

535067

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.536

High

931237

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

1133863

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

10

High-throughput

0.536

High

341421

CDS2
Phosphatidate cytidylyltransferase 2

1

1

High-throughput

0.515

High

584021

FOSL1
Fos-related antigen 1

1

1

High-throughput

0.515

High

867707

RGR
RPE-retinal G protein-coupled receptor

1

7

High-throughput

0.515

High

1111537

STIM1
Stromal interaction molecule 1

1

6

High-throughput

0.515

High

1133864

RHEB
GTP-binding protein Rheb

1

9

High-throughput

0.515

High

1133902

RAB2B
Ras-related protein Rab-2B

1

3

High-throughput

0.515

High

1133916

DPYL5
Dihydropyrimidinase-related protein 5

1

7

High-throughput

0.515

High

1133926

SEM4G
Semaphorin-4G

1

1

High-throughput

0.515

High

1133930

DBNL
Drebrin-like protein

1

15

High-throughput

0.515

High

136606

MANBA
Beta-mannosidase

1

0

High-throughput

0.513

High

441427

CHLE
Cholinesterase

1

0

High-throughput

0.513

High

1091494

DLG1
Disks large homolog 1

1

20

High-throughput

0.501

High

532586

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

783272

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.493

High

1133903

CHMP7
Charged multivesicular body protein 7

1

0

High-throughput

0.493

High

1133907

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.493

High

1133929

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.493

High

996951

TBA4A
Tubulin alpha-4A chain

1

8

High-throughput

0.489

High

1133932

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.489

High

1113127

CUL3
Cullin-3

1

3

High-throughput

0.479

High

85130

B7Z3E8
cDNA FLJ51208

1

1

High-throughput

0.470

High

193775

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.470

High

239315

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

4

High-throughput

0.470

High

1055654

GABP1
GA-binding protein subunit beta-1

1

5

High-throughput

0.470

High

1060604

PPARA
Peroxisome proliferator-activated receptor alpha

1

3

High-throughput

0.470

High

1103902

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

2

High-throughput

0.470

High

1120599

DPYS
Dihydropyrimidinase

1

7

High-throughput

0.470

High

1133083

LASP1
LIM and SH3 domain protein 1

1

10

High-throughput

0.470

High

1133866

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

3

High-throughput

0.470

High

1133867

ZN829
Zinc finger protein 829

1

1

High-throughput

0.470

High

1133873

ODFP2
Outer dense fiber protein 2

1

5

High-throughput

0.470

High

1133874

CD158
Coiled-coil domain-containing protein 158

1

6

High-throughput

0.470

High

1133878

HECD3
E3 ubiquitin-protein ligase HECTD3

1

9

High-throughput

0.470

High

1133882

LHX8
LIM/homeobox protein Lhx8

1

1

High-throughput

0.470

High

1133883

OTU7B
OTU domain-containing protein 7B

1

2

High-throughput

0.470

High

1133886

Q6PHZ7
NR2C2 protein

1

3

High-throughput

0.470

High

1133889

DEFI8
Differentially expressed in FDCP 8 homolog

1

11

High-throughput

0.470

High

1133890

PKHG7
Pleckstrin homology domain-containing family G member 7

1

12

High-throughput

0.470

High

1133895

TMTC1
Protein O-mannosyl-transferase TMTC1

1

1

High-throughput

0.470

High

1133919

RN208
RING finger protein 208

1

1

High-throughput

0.470

High

1133920

LHX5
LIM/homeobox protein Lhx5

1

1

High-throughput

0.470

High

1133925

BRWD1
Bromodomain and WD repeat-containing protein 1

1

1

High-throughput

0.470

High

1133931

BRPF3
Bromodomain and PHD finger-containing protein 3

1

1

High-throughput

0.470

High

1133935

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.470

High

1133862

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.437

High

1133893

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

1133898

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.279

Low

2017

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.268

Low

48292

E2F8
Transcription factor E2F8

1

0

High-throughput

0.268

Low

137330

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.268

Low

185094

TELT
Telethonin

1

0

High-throughput

0.268

Low

217092

MS18B
Protein Mis18-beta

1

0

High-throughput

0.268

Low

219174

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.268

Low

225591

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.268

Low

229329

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.268

Low

1133927

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

1133928

IL37
Interleukin-37

1

0

High-throughput

0.268

Low

1133933

TRI35
E3 ubiquitin-protein ligase TRIM35

1

0

High-throughput

0.268

Low

1133934

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.268

Low

257542

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

0

High-throughput

0.268

Low

261009

SHOX2
Short stature homeobox protein 2

1

0

High-throughput

0.268

Low

384255

CO2A1
Collagen alpha-1(II) chain

1

0

High-throughput

0.268

Low

443064

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.268

Low

621875

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.268

Low

667854

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.268

Low

834642

NBL1
Neuroblastoma suppressor of tumorigenicity 1

1

0

High-throughput

0.268

Low

884336

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.268

Low

928454

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.268

Low

975400

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.268

Low

977249

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.268

Low

1054585

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.268

Low

1110980

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.268

Low

1133868

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.268

Low

1133869

Q495U3
PANX2 protein

1

0

High-throughput

0.268

Low

1133870

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

1133871

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.268

Low

1133872

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

1133875

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

0

High-throughput

0.268

Low

1133876

PKHS1
Pleckstrin homology domain-containing family S member 1

1

0

High-throughput

0.268

Low

1133877

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.268

Low

1133879

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.268

Low

1133880

EF1DL
Putative elongation factor 1-delta-like protein

1

0

High-throughput

0.268

Low

1133881

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.268

Low

1133884

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.268

Low

1133885

TT23L
Tetratricopeptide repeat protein 23-like

1

0

High-throughput

0.268

Low

1133887

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.268

Low

1133888

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

1133891

KHDC4
KH homology domain-containing protein 4

1

0

High-throughput

0.268

Low

1133892

DPPA2
Developmental pluripotency-associated protein 2

1

0

High-throughput

0.268

Low

1133894

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.268

Low

1133896

TMM61
Transmembrane protein 61

1

0

High-throughput

0.268

Low

1133897

CF218
Putative uncharacterized protein encoded by LINC00518

1

0

High-throughput

0.268

Low

1133899

ICA1L
Islet cell autoantigen 1-like protein

1

0

High-throughput

0.268

Low

1133900

Q8NDP9
HCG2036974

1

0

High-throughput

0.268

Low

1133901

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.268

Low

1133904

RN138
E3 ubiquitin-protein ligase RNF138

1

0

High-throughput

0.268

Low

1133906

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.268

Low

1133908

F163A
Protein FAM163A

1

0

High-throughput

0.268

Low

1133909

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.268

Low

1133910

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.268

Low

1133911

ZN333
Zinc finger protein 333

1

0

High-throughput

0.268

Low

1133912

CH048
Uncharacterized protein C8orf48

1

0

High-throughput

0.268

Low

1133913

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.268

Low

1133915

NPAS2
Neuronal PAS domain-containing protein 2

1

0

High-throughput

0.268

Low

1133917

HAUS8
HAUS augmin-like complex subunit 8

1

0

High-throughput

0.268

Low

1133918

TEX12
Testis-expressed protein 12

1

0

High-throughput

0.268

Low

1133921

GO45
Golgin-45

1

0

High-throughput

0.268

Low

1133922

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.268

Low

1133923

MYOZ2
Myozenin-2

1

0

High-throughput

0.268

Low

1133924

PAR11
Protein mono-ADP-ribosyltransferase PARP11

1

0

High-throughput

0.268

Low

1133865

KAT1
Kynurenine--oxoglutarate transaminase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025