HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035591 - signaling adaptor activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 694 Hs			1 456
+	Hs
		129290 GAB1_HUMAN (1-694): 0: 547: 100.00		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		655356 GAB1_HUMAN (1-694): 0: 547: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		643113 GAB1_MOUSE (1-694): 0: 544: 89.93		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		1035395 GAB1_HUMAN (1-694): 0: 547: 100.00		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		1035381 GAB1_HUMAN (1-694): 0: 547: 100.00		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Mm
		1193573 GAB1_MOUSE (1-694): 0: 544: 89.93		Q80UI5_MOUSE (341-453): 2.48e-25: 109: 27.43
+	Hs
		1035409 GAB1_HUMAN (1-694): 0: 547: 100.00		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		1035389 GAB1_HUMAN (1-694): 0: 547: 100.00		TENS4_HUMAN (81-436): 3.69e-20: 95.6: 13.70
+	Hs
		129351 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		655510 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		140067 GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33		P85B_MOUSE (131-453): 3.36e-43: 163: 16.27
+	Mm
		140061 Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33		P85B_MOUSE (131-453): 3.36e-43: 163: 16.27
+	Mm
		643089 Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		203234 PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07		SYNJ1_HUMAN (40-436): 8.64e-25: 110: 12.71
+	Hs
		1132070 PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		867129 PKHA2_HUMAN (2-210): 3.77e-36: 143: 19.28		SC24C_HUMAN (93-403): 1.41e-23: 106: 12.23
+	Dm
		113976 M9PB30_DROME (113-693): 9.4e-14: 77.5: 13.46		M9PB30_DROME (25-304): 2.19e-09: 62.1: 10.99