Protein: PDK2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)

Gene: PDK2
Organism: Homo sapiens
Interactions: 35
UniProt ID: Q15119

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142546

PDK1
[Pyruvate dehydrogenase

7

11

Small-scale

0.964

High

1142723

PDK3
[Pyruvate dehydrogenase

3

11

High-throughput

0.871

High

1142724

PDK4
[Pyruvate dehydrogenase

3

11

High-throughput

0.855

High

461493

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

468389

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

539180

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

6

High-throughput

0.667

High

1142733

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

6

High-throughput

0.667

High

653326

HEMH
Ferrochelatase, mitochondrial

3

1

High-throughput

0.662

High

838363

STA5A
Signal transducer and activator of transcription 5A

2

2

High-throughput

0.628

High

522428

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

9

Small-scale

0.602

High

85097

B7Z207
Protein-serine/threonine kinase

1

11

High-throughput

0.575

High

1091182

FOXD4
Forkhead box protein D4

2

3

High-throughput

0.574

High

1142728

SYT12
Synaptotagmin-12

2

1

High-throughput

0.574

High

471035

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

10

Small-scale

0.571

High

843574

HD
Huntingtin

2

0

High-throughput

0.571

High

731314

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.536

High

869162

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

4

High-throughput

0.536

High

1105930

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

6

High-throughput

0.536

High

1142725

P5CR3
Pyrroline-5-carboxylate reductase 3

1

4

High-throughput

0.536

High

1142732

NPS3B
Protein NipSnap homolog 3B

1

3

High-throughput

0.536

High

1142736

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.513

High

132849

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

9

Small-scale

0.501

High

1142735

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.494

High

409388

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.489

High

520851

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.489

High

241733

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

551709

HARS1
Histidine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

1083615

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

1142726

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1142727

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.479

High

1142734

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

1

Small-scale

0.479

High

573111

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.458

High

1142729

ISOC2
Isochorismatase domain-containing protein 2

1

0

High-throughput

0.438

High

1142730

HIC2
Hypermethylated in cancer 2 protein

1

0

High-throughput

0.438

High

1142731

SPTCS
Spatacsin

1

0

Small-scale

0.438

High


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Last updated: 11Aug2025