Protein: PDK4
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)

Gene: PDK4
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q16654

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142737

PDK3
[Pyruvate dehydrogenase

4

11

High-throughput

0.900

High

1142724

PDK2
[Pyruvate dehydrogenase

3

11

High-throughput

0.855

High

1142551

PDK1
[Pyruvate dehydrogenase

2

11

High-throughput

0.789

High

461532

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

468424

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

1160951

SYNM
Asparaginyl-tRNA synthetase

2

3

High-throughput

0.628

High

1160949

COA7
Cytochrome c oxidase assembly factor 7

2

0

High-throughput

0.576

High

85099

B7Z207
Protein-serine/threonine kinase

1

11

High-throughput

0.575

High

471044

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

10

Small-scale

0.552

High

610682

TCPA
T-complex protein 1 subunit alpha

1

11

High-throughput

0.536

High

786108

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.536

High

821372

TCPZ
T-complex protein 1 subunit zeta

1

11

High-throughput

0.536

High

841015

FRK
Tyrosine-protein kinase FRK

1

1

High-throughput

0.536

High

875978

TCPE
T-complex protein 1 subunit epsilon

1

14

High-throughput

0.536

High

881943

TCPG
T-complex protein 1 subunit gamma

1

14

High-throughput

0.536

High

899055

TCPQ
T-complex protein 1 subunit theta

1

17

High-throughput

0.536

High

899403

TCPD
T-complex protein 1 subunit delta

1

11

High-throughput

0.536

High

932470

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.536

High

1007034

TCPB
T-complex protein 1 subunit beta

1

14

High-throughput

0.536

High

1160950

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.536

High

1160954

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

1160956

TCPH
T-complex protein 1 subunit eta

1

14

High-throughput

0.536

High

1160964

TR150
Thyroid hormone receptor-associated protein 3

1

3

High-throughput

0.515

High

697550

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.513

High

722972

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

1160945

UHMK1
Serine/threonine-protein kinase Kist

1

0

High-throughput

0.513

High

1160946

TITIN
Titin

1

0

High-throughput

0.513

High

124786

AIP
AH receptor-interacting protein

1

3

High-throughput

0.489

High

172865

XPO1
Exportin-1

1

1

High-throughput

0.489

High

273870

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.489

High

568647

GYS1
Glycogen [starch] synthase, muscle

1

1

High-throughput

0.489

High

1144005

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.489

High

1160145

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.489

High

1160947

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.489

High

1160952

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

2

High-throughput

0.489

High

1160955

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

1160961

CNOT2
CCR4-NOT transcription complex subunit 2

1

1

High-throughput

0.489

High

1029098

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

653340

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

1160948

TRI63
E3 ubiquitin-protein ligase TRIM63

1

4

Small-scale

0.439

High

1160958

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

64025

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.279

Low

175062

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.279

Low

249755

DOK2
Docking protein 2

1

0

High-throughput

0.279

Low

1160943

NU188
Nucleoporin NUP188

1

0

High-throughput

0.279

Low

1160944

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.279

Low

1160953

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.279

Low

1160957

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

1160959

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.279

Low

1160960

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.279

Low

1160962

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.279

Low

1160963

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025