HitPredict

Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	27552911, 21408173, 17702576, 22675546
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043124 - negative regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 577
+	Hs
		1038348 RIPK1_HUMAN (1-671): 0: 610: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Mm
		1141531 RIPK1_MOUSE (1-671): 0: 575: 69.49		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Mm
		291803 RIPK1_MOUSE (1-671): 0: 575: 69.49		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		148774 RIPK1_HUMAN (1-671): 0: 610: 100.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		1038347 RIPK1_HUMAN (1-671): 0: 610: 100.00		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		201391 M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		201491 M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Mm
		291805 M3K7_MOUSE (4-611): 1.21e-120: 373: 19.12		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		883695 RIPK4_HUMAN (14-280): 7.4e-33: 137: 34.31		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1330909 Q9H4D1_HUMAN (14-281): 1.82e-32: 135: 34.18		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Mm
		291785 RIPK2_MOUSE (55-369): 5.14e-32: 132: 29.57		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		201840 RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		433781 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		725275 RIPK3_HUMAN (18-286): 1.57e-32: 134: 33.33		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		433558 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		201767 RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		433795 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		201766 RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		433620 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		434101 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77