HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 344
+	Hs
		1041499 KMT2A_HUMAN (1-3969): 0: 3227: 100.00		SRSF4_HUMAN (1-323): 1.86e-45: 163: 63.47
+	Hs
		1041509 KMT2A_HUMAN (1-3969): 0: 3227: 100.00		SRSF5_HUMAN (2-180): 3.8e-46: 160: 64.25
+	Hs
		1060998 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		SRSF1_HUMAN (3-188): 3.03e-54: 180: 36.65
+	Hs
		1098974 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		SRSF9_HUMAN (3-222): 5.62e-49: 165: 34.22
+	Hs
		1099091 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		SRSF5_HUMAN (2-180): 3.8e-46: 160: 64.25
+	Hs
		1099518 SETD2_HUMAN (3398-3968): 9.76e-78: 291: 15.76		SRSF6_HUMAN (1-322): 1.01e-43: 155: 100.00
+	Hs
		1028992 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		TIAR_HUMAN (2-120): 8.39e-14: 73.4: 17.89
+	Hs
		1101972 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		PABP4_HUMAN (105-191): 8.58e-13: 71.1: 22.83
+	Hs
		1155825 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		RBM28_HUMAN (4-248): 1.81e-12: 70.3: 14.61
+	Hs
		550304 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		PABP1_HUMAN (100-191): 9.12e-12: 68: 19.59
+	Hs
		1016457 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		SRSF3_HUMAN (3-78): 2.42e-09: 57.4: 46.84
+	Mm
		1016696 Q6AXH7_MOUSE (3450-3951): 3.07e-102: 349: 18.03		SRSF3_MOUSE (3-78): 2.42e-09: 57.4: 46.84
+	Hs
		355505 NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23		SRSF4_HUMAN (1-323): 1.86e-45: 163: 63.47
+	Hs
		355586 NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23		RBM4B_HUMAN (1-343): 1.76e-46: 163: 17.95
+	Hs
		355512 NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23		SRSF5_HUMAN (2-180): 3.8e-46: 160: 64.25
+	Hs
		355513 NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23		SRSF6_HUMAN (1-322): 1.01e-43: 155: 100.00
+	Sc
		403558 SET2_YEAST (3811-3968): 1.52e-56: 214: 29.56		PABP_YEAST (3-190): 1.08e-31: 126: 17.50
+	Pf
		91248 SET1_PLAF7 (1476-1625): 2.3e-46: 188: 28.76		Q8I3T5_PLAF7 (3-289): 3.89e-38: 139: 28.48
+	Sc
		676742 SET2_YEAST (3811-3968): 1.52e-56: 214: 29.56		GBP2_YEAST (4-203): 4.82e-23: 100: 19.05
+	Hs
		550367 KMT2C_HUMAN (1816-1977): 4.38e-11: 72.1: 24.10		PABP1_HUMAN (100-191): 9.12e-12: 68: 19.59