HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 272
+	Hs
		355505 NSD2_HUMAN (1-1365): 0: 988: 100.00		SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64
+	Hs
		355513 NSD2_HUMAN (1-1365): 0: 988: 100.00		SRSF6_HUMAN (5-184): 1.34e-48: 165: 61.96
+	Hs
		1060998 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68
+	Hs
		1099091 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00
+	Hs
		1098974 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		SRSF9_HUMAN (2-211): 1.48e-52: 172: 33.02
+	Hs
		1099518 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		SRSF6_HUMAN (5-184): 1.34e-48: 165: 61.96
+	Hs
		1041509 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00
+	Hs
		1041499 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64
+	Hs
		1041510 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		SRSF6_HUMAN (5-184): 1.34e-48: 165: 61.96
+	Sc
		403558 SET2_YEAST (972-1208): 1.23e-61: 227: 35.12		PABP_YEAST (86-192): 6.13e-15: 76.3: 19.64
+	Hs
		1101972 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		PABP4_HUMAN (104-189): 2.67e-16: 80.1: 21.98
+	Hs
		550304 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		PABP1_HUMAN (98-189): 8.49e-16: 79: 18.56
+	Hs
		1028992 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		TIAR_HUMAN (3-103): 2.99e-12: 67.8: 14.56
+	Hs
		1016457 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		SRSF3_HUMAN (4-78): 1.86e-11: 62.8: 47.56
+	Mm
		1016696 Q6AXH7_MOUSE (904-1188): 1.19e-58: 218: 22.48		SRSF3_MOUSE (4-78): 1.86e-11: 62.8: 47.56
+	Zm
		6360 A0A1D6EZN1_MAIZE (1046-1202): 5.59e-56: 201: 32.62		A0A1D6E6L1_MAIZE (103-192): 1.6e-15: 77.8: 25.26
+	Dm
		356721 CHDM_DROME (1238-1285): 6.81e-12: 72.7: 42.00		SRR55_DROME (1-179): 1.67e-56: 187: 58.64
+	Hs
		550417 NSD1_HUMAN (69-658): 8.18e-26: 118: 14.33		PABP1_HUMAN (98-189): 8.49e-16: 79: 18.56