HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: MICA3 (Q7RTP6)
[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
Gene: MICAL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	27528609
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0042995 - cell projection
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2472 Hs			1 2002
+	Hs
		963358 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MICA3_HUMAN (1-2002): 0: 1314: 100.00
+	Rn
		555261 SPTN1_RAT (1-2472): 0: 713: 98.58		ACTN1_RAT (434-1065): 4.65e-104: 358: 14.82
+	Rn
		555258 SPTN1_RAT (1-2472): 0: 713: 98.58		Q6XD99_RAT (433-1059): 3.06e-87: 320: 16.56
+	Hs
		963320 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		506818 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTB1_HUMAN (433-1059): 1.05e-83: 309: 16.54
+	Hs
		164614 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Dm
		527098 SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92		Q7KV70_DROME (454-1422): 3.31e-88: 324: 16.20
+	Ce
		103424 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		H2L2C8_CAEEL (434-1042): 7.69e-96: 332: 14.93
+	Dm
		527092 SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92		SPTCB_DROME (433-1103): 4.7e-82: 303: 15.47
+	Ce
		103420 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		G5EG85_CAEEL (433-812): 4.69e-81: 300: 19.27
+	Hs
		360638 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		360607 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SPTB1_HUMAN (433-1059): 1.05e-83: 309: 16.54
+	Hs
		1045418 SPTN1_HUMAN (1-2472): 0: 714: 100.00		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87
+	Hs
		360644 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87
+	Hs
		164603 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Rn
		1167662 Q6XD99_RAT (2-1043): 2.15e-37: 157: 20.32		ACTN1_RAT (434-1065): 4.65e-104: 358: 14.82
+	Hs
		963291 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Dm
		54298 A1Z9J2_DROME (1-736): 1.22e-28: 129: 17.12		Q7KV70_DROME (454-1422): 3.31e-88: 324: 16.20
+	Hs
		1068536 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87