HitPredict

Interactor 1: VGLL4 (Q14135)
Transcription cofactor vestigial-like protein 4 (Vgl-4)
Gene: VGLL4

Interactor 2: TEAD4 (Q15561)
Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
Gene: TEAD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	31559693, 26186194, 28514442, 33961781, 24525233
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, bio-layer interferometry, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	VGLL4~YBD
Common GO terms	GO:0005634 - nucleus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 290 Hs			1 434
+	Hs
		658497 VGLL4_HUMAN (1-290): 6.35e-180: 498: 100.00		TEAD1_HUMAN (8-434): 0: 733: 74.54
+	Mm
		1143752 VGLL4_MOUSE (23-279): 8.76e-156: 437: 87.94		TEAD4_MOUSE (8-434): 0: 770: 93.68
+	Hs
		1048842 VGLL4_HUMAN (1-290): 6.35e-180: 498: 100.00		TEAD3_HUMAN (21-434): 0: 691: 70.82
+	Hs
		1048837 VGLL4_HUMAN (1-290): 6.35e-180: 498: 100.00		TEAD2_HUMAN (40-434): 0: 648: 65.93