HitPredict

Interactor 1: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Interactor 2: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	24067654, 20562859, 20495340
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 624 Hs			1 121
+	Hs
		891139 KEAP1_HUMAN (1-624): 0: 584: 100.00		GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74
+	Hs
		1049322 KEAP1_HUMAN (1-624): 0: 584: 100.00		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Hs
		306167 KEAP1_HUMAN (1-624): 0: 584: 100.00		GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44
+	Hs
		1049326 KEAP1_HUMAN (1-624): 0: 584: 100.00		GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05
+	Dm
		1181841 Q7KSF5_DROME (423-623): 8.77e-52: 192: 31.22		Q9W2S2_DROME (3-121): 3.47e-53: 164: 30.25
+	Hs
		891272 KLHL5_HUMAN (470-624): 2.33e-44: 171: 38.71		GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74
+	Hs
		1299556 KLHL5_HUMAN (470-624): 2.33e-44: 171: 38.71		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Hs
		1120814 KLH12_HUMAN (498-623): 1.05e-20: 98.3: 26.92		MLP3A_HUMAN (1-121): 4.19e-54: 167: 100.00
+	Hs
		1120811 KLH12_HUMAN (498-623): 1.05e-20: 98.3: 26.92		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82