Protein: PTN14
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)

Gene: PTN14, PTPN14
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q15678

Gene Ontology (top 5):
GO:0001946 - lymphangiogenesis
GO:0003712 - transcription coregulator activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862166

YAP1
Transcriptional coactivator YAP1

14

20

Small-scale

0.763

High

375547

RASK
GTPase KRas

2

20

High-throughput

0.754

High

978028

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1152014

KIBRA
Protein KIBRA

8

20

Small-scale

0.746

High

729863

1433B
14-3-3 protein beta/alpha

7

20

Small-scale

0.745

High

966349

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

1049320

1433F
14-3-3 protein eta

5

20

High-throughput

0.712

High

1152050

PDLI7
PDZ and LIM domain protein 7

4

20

High-throughput

0.699

High

1151989

AMOT
Angiomotin

4

20

Small-scale

0.677

High

349093

LATS1
Serine/threonine-protein kinase LATS1

4

11

Small-scale

0.676

High

372121

MYC
Myc proto-oncogene protein

3

7

High-throughput

0.667

High

1152030

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

3

20

High-throughput

0.667

High

1152036

PAR6B
Partitioning defective 6 homolog beta

3

12

High-throughput

0.667

High

971558

1433E
14-3-3 protein epsilon

3

6

Small-scale

0.662

High

132066

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

11

Small-scale

0.640

High

1151996

WWC2
Protein WWC2

3

20

Small-scale

0.640

High

1152039

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

3

11

Small-scale

0.640

High

1152004

STXB4
Syntaxin-binding protein 4

4

20

High-throughput

0.633

High

1151991

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

2

20

High-throughput

0.628

High

1152035

PHF20
PHD finger protein 20

2

7

High-throughput

0.628

High

990259

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.621

High

155161

SOCS7
Suppressor of cytokine signaling 7

1

15

Small-scale

0.618

High

440088

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463535

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

582810

EZRI
Ezrin

1

18

High-throughput

0.618

High

955200

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962080

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

988390

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1151984

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

18

High-throughput

0.618

High

1152002

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1152013

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.618

High

1152031

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.618

High

691035

1433T
14-3-3 protein theta

2

20

High-throughput

0.612

High

1152005

ACD11
Acyl-CoA dehydrogenase family member 11

2

2

High-throughput

0.611

High

1151513

TRIP6
Thyroid receptor-interacting protein 6

2

18

High-throughput

0.606

High

1152015

RHPN1
Rhophilin-1

3

14

High-throughput

0.604

High

1152027

JPH4
Junctophilin-4

3

4

High-throughput

0.604

High

1151990

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.586

High

347718

BAG3
BAG family molecular chaperone regulator 3

2

4

High-throughput

0.584

High

919988

PLK1
Serine/threonine-protein kinase PLK1

2

8

Small-scale

0.584

High

1097671

STK3
Serine/threonine-protein kinase 3

2

8

Small-scale

0.584

High

1112850

CUL2
Cullin-2

2

6

Small-scale

0.584

High

1152009

MOB1B
MOB kinase activator 1B

2

7

High-throughput

0.584

High

1152029

LLR1
Leucine-rich repeat protein 1

2

4

Small-scale

0.584

High

1152034

CSN4
COP9 signalosome complex subunit 4

2

4

Small-scale

0.584

High

1152046

MOB1A
MOB kinase activator 1A

2

7

High-throughput

0.584

High

710261

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

962749

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.553

High

1144915

RAB35
Ras-related protein Rab-35

1

14

High-throughput

0.553

High

1152042

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

1152055

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

12

High-throughput

0.553

High

963296

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.536

High

1152070

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

886496

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

1152011

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.513

High

706134

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

1152032

SCN2A
Sodium channel protein type 2 subunit alpha

1

10

High-throughput

0.489

High

122776

KIF2A
Kinesin-like protein KIF2A

1

11

High-throughput

0.479

High

174516

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.479

High

176827

DCLK1
Serine/threonine-protein kinase DCLK1

1

6

High-throughput

0.479

High

181705

CTDSL
CTD small phosphatase-like protein

1

4

High-throughput

0.479

High

208668

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

5

High-throughput

0.479

High

230030

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

8

High-throughput

0.479

High

245233

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

7

High-throughput

0.479

High

252071

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

269556

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

17

High-throughput

0.479

High

327270

ZFPL1
Zinc finger protein-like 1

1

5

High-throughput

0.479

High

332304

ATE1
Arginyl-tRNA--protein transferase 1

1

1

High-throughput

0.479

High

400886

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.479

High

437188

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

447060

NPM
Nucleophosmin

1

3

High-throughput

0.479

High

508024

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

532608

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

577770

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

588788

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

603993

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

637902

NF1
Neurofibromin

1

10

High-throughput

0.479

High

692071

MARK3
MAP/microtubule affinity-regulating kinase 3

1

7

Small-scale

0.479

High

715598

MARCS
Myristoylated alanine-rich C-kinase substrate

1

10

High-throughput

0.479

High

717821

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

Small-scale

0.479

High

730607

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731330

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

749775

CADH5
Cadherin-5

1

20

Small-scale

0.479

High

764342

CTNA1
Catenin alpha-1

1

5

Small-scale

0.479

High

764780

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

822680

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

877121

KC1D
Casein kinase I isoform delta

1

8

Small-scale

0.479

High

936336

AFAD
Afadin

1

20

High-throughput

0.479

High

940975

HDAC4
Histone deacetylase 4

1

8

High-throughput

0.479

High

951691

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.479

High

975051

ARF6
ADP-ribosylation factor 6

1

10

High-throughput

0.479

High

991030

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.479

High

1004066

CXAR
Coxsackievirus and adenovirus receptor

1

14

High-throughput

0.479

High

1045328

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1051240

KPCZ
Protein kinase C zeta type

1

13

High-throughput

0.479

High

1058841

ZO1
Tight junction protein 1

1

20

Small-scale

0.479

High

1094340

CSN1
COP9 signalosome complex subunit 1

1

6

High-throughput

0.479

High

1102549

MTA1
Metastasis-associated protein MTA1

1

5

High-throughput

0.479

High

1113191

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1151985

ZYX
Zyxin

1

20

High-throughput

0.479

High

1151986

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

1151992

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.479

High

1152000

RBP10
Ran-binding protein 10

1

8

High-throughput

0.479

High

1152001

SYNE3
Nesprin-3

1

16

High-throughput

0.479

High

1152006

MOB3C
MOB kinase activator 3C

1

7

High-throughput

0.479

High

1152008

MAEA
E3 ubiquitin-protein transferase MAEA

1

11

High-throughput

0.479

High

1152010

MOB3B
MOB kinase activator 3B

1

7

High-throughput

0.479

High

1152012

ARMC8
Armadillo repeat-containing protein 8

1

4

High-throughput

0.479

High

1152016

BICD2
Protein bicaudal D homolog 2

1

9

High-throughput

0.479

High

1152019

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1152020

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

1152022

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.479

High

1152025

MOB3A
MOB kinase activator 3A

1

7

High-throughput

0.479

High

1152026

BICD1
Protein bicaudal D homolog 1

1

9

High-throughput

0.479

High

1152028

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

8

High-throughput

0.479

High

1152038

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1152041

SAV1
Protein salvador homolog 1

1

20

High-throughput

0.479

High

1152043

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1152044

WDR26
WD repeat-containing protein 26

1

14

High-throughput

0.479

High

1152045

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

8

High-throughput

0.479

High

1152048

KI13B
Kinesin-like protein KIF13B

1

12

High-throughput

0.479

High

1152049

ANLN
Anillin

1

8

High-throughput

0.479

High

1152051

LATS2
Serine/threonine-protein kinase LATS2

1

13

High-throughput

0.479

High

1152052

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

4

High-throughput

0.479

High

1152053

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

1152054

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1152057

HECW2
E3 ubiquitin-protein ligase HECW2

1

11

High-throughput

0.479

High

1152060

XPO7
Exportin-7

1

15

High-throughput

0.479

High

1152062

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

1152064

PPM1H
Protein phosphatase 1H

1

2

High-throughput

0.479

High

1152066

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1152068

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

59919

A2BDD9
AMOT protein

1

14

High-throughput

0.470

High

1060443

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.458

High

1133968

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1151997

AMERL
AMMECR1-like protein

1

0

High-throughput

0.458

High

1152021

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.458

High

566270

K1C13
Keratin, type I cytoskeletal 13

1

1

High-throughput

0.445

High

725609

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

High-throughput

0.445

High

942634

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.445

High

1151988

INAVA
Innate immunity activator protein

1

1

High-throughput

0.445

High

1152007

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

7

High-throughput

0.445

High

1152067

TRAK1
Trafficking kinesin-binding protein 1

1

13

High-throughput

0.445

High

124356

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

139878

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

189579

STX7
Syntaxin-7

1

12

High-throughput

0.437

High

281327

GGYF1
GRB10-interacting GYF protein 1

1

6

High-throughput

0.437

High

299210

FLOT1
Flotillin-1

1

13

High-throughput

0.437

High

845653

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.437

High

878468

PAXI
Paxillin

1

17

High-throughput

0.437

High

896534

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.437

High

1041083

CAV1
Caveolin-1

1

8

High-throughput

0.437

High

1053484

ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3

1

3

High-throughput

0.437

High

1151987

OCLN
Occludin

1

9

High-throughput

0.437

High

1151993

DEN4C
DENN domain-containing protein 4C

1

6

High-throughput

0.437

High

1151994

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1151995

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.437

High

1151998

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.437

High

1151999

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1152003

SYDE1
Rho GTPase-activating protein SYDE1

1

19

High-throughput

0.437

High

1152017

BPIB1
BPI fold-containing family B member 1

1

3

High-throughput

0.437

High

1152018

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.437

High

1152023

CK052
Uncharacterized protein C11orf52

1

8

High-throughput

0.437

High

1152024

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.437

High

1152033

RTKN
Rhotekin

1

1

High-throughput

0.437

High

1152037

NDEL1
Nuclear distribution protein nudE-like 1

1

7

High-throughput

0.437

High

1152040

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.437

High

1152047

RC3H2
Roquin-2

1

11

High-throughput

0.437

High

1152056

CING
Cingulin

1

3

High-throughput

0.437

High

1152059

LIMA1
LIM domain and actin-binding protein 1

1

18

High-throughput

0.437

High

1152061

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

1152063

ANR50
Ankyrin repeat domain-containing protein 50

1

13

High-throughput

0.437

High

1152065

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

High-throughput

0.437

High

1152069

KCTD3
BTB/POZ domain-containing protein KCTD3

1

12

High-throughput

0.437

High

943241

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.426

High

1152058

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.407

High

168853

PLD2
Phospholipase D2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025