HitPredict

Interactor 1: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 365
+	Hs
		118804 AIP_HUMAN (97-369): 4.45e-54: 184: 18.94		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1053193 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		1028045 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		174884 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		972614 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1035065 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		73118 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		B4DYC6_HUMAN (57-365): 4.31e-64: 207: 86.41
+	Sc
		549767 STI1_YEAST (221-371): 6.12e-25: 108: 19.21		SGT1_YEAST (12-365): 5.06e-48: 168: 24.87
+	Hs
		213490 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		SGTA_HUMAN (6-171): 3.42e-40: 146: 20.96
+	Hs
		684549 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Dm
		1366835 Q9VPN5_DROME (218-345): 7.56e-18: 87.3: 19.53		Q9VH81_DROME (4-218): 1.63e-39: 148: 13.58
+	Hs
		858619 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Dm
		817472 FKB12_DROME (107-204): 8.02e-34: 123: 33.33		Q9VPN5_DROME (1-321): 9.76e-18: 86: 10.98
+	Hs
		685029 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		1034998 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		174814 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Sc
		549696 STI1_YEAST (221-371): 6.12e-25: 108: 19.21		STI1_YEAST (2-145): 1.79e-14: 76.4: 23.61
+	Hs
		174661 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		174855 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		297056 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29