HitPredict

Interactor 1: RPN7 (Q06103)
26S proteasome regulatory subunit RPN7
Gene: RPN7

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	37968396, 16554755, 16429126, 19446323, 31848235
Identification Methods	affinity chromatography technology, cross-linking study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MitMem_reg~PCI, MitMem_reg~RPN7_PSMD6_C
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0008541 - proteasome regulatory particle, lid subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 429 Sc			1 338
+	Hs
		906522 PSMD6_HUMAN (15-423): 3.17e-123: 364: 35.21		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	Dm
		684554 PSMD6_DROME (15-423): 4.19e-114: 341: 33.99		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Mm
		107988 G3UXW9_MOUSE (2-424): 2.06e-117: 354: 20.63		CSN6_MOUSE (3-300): 2.13e-90: 275: 22.04
+	Mm
		312566 CSN1_MOUSE (2-424): 6.04e-116: 349: 20.63		CSN6_MOUSE (3-300): 2.13e-90: 275: 22.04
+	Hs
		1094361 CSN1_HUMAN (2-424): 2.22e-112: 340: 20.00		CSN6_HUMAN (3-300): 3.85e-91: 277: 22.04
+	Dm
		1470905 CSN1_DROME (9-426): 1.01e-103: 319: 16.88		CSN6_DROME (2-307): 2.8e-86: 265: 20.19
+	Hs
		958664 CSN2_HUMAN (20-422): 4.33e-98: 302: 12.10		CSN6_HUMAN (3-300): 3.85e-91: 277: 22.04
+	Mm
		312564 CSN2_MOUSE (20-422): 4.33e-98: 302: 12.10		CSN6_MOUSE (3-300): 2.13e-90: 275: 22.04
+	Dm
		684549 PSD11_DROME (1-426): 2.29e-84: 266: 11.57		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Dm
		1375264 CSN2_DROME (5-412): 4.82e-94: 292: 11.95		CSN6_DROME (2-307): 2.8e-86: 265: 20.19
+	Sp
		836447 RPN7_SCHPO (14-421): 4.12e-106: 321: 40.69		RPN11_SCHPO (1-263): 3.36e-61: 199: 19.11
+	Dm
		1463468 PSMD6_DROME (15-423): 4.19e-114: 341: 33.99		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Dm
		1487494 CSN1_DROME (9-426): 1.01e-103: 319: 16.88		CSN5_DROME (6-160): 1.71e-51: 175: 20.63
+	At
		852155 CSN1_ARATH (25-428): 2.04e-105: 320: 18.72		CSN5B_ARATH (6-160): 3.12e-48: 167: 20.00
+	At
		852147 CSN1_ARATH (25-428): 2.04e-105: 320: 18.72		CSN5A_ARATH (6-160): 3.7e-47: 164: 20.63
+	Hs
		138114 PSMD6_HUMAN (15-423): 3.17e-123: 364: 35.21		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	Dm
		1375273 CSN2_DROME (5-412): 4.82e-94: 292: 11.95		CSN5_DROME (6-160): 1.71e-51: 175: 20.63
+	At
		1355338 CSN2_ARATH (4-421): 6.86e-97: 298: 13.30		CSN5B_ARATH (6-160): 3.12e-48: 167: 20.00
+	At
		1319392 CSN2_ARATH (4-421): 6.86e-97: 298: 13.30		CSN5A_ARATH (6-160): 3.7e-47: 164: 20.63
+	Dm
		1267334 PSD11_DROME (1-426): 2.29e-84: 266: 11.57		PSDE_DROME (3-264): 6.48e-48: 165: 16.90