HitPredict

Interactor 1: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1233 Hs			1 530
+	Hs
		369610 SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377326 SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		311597 SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269723 SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269952 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		311456 SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370526 SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370733 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782697 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		487432 SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		724944 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1270044 MYH4_HUMAN (659-1132): 9.83e-17: 88.2: 10.58		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369096 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		522631 MYH7_HUMAN (51-420): 1.04e-10: 68.6: 13.37		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368902 MYH6_HUMAN (51-434): 4.09e-11: 70.1: 13.14		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		587127 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		377795 MYH2_HUMAN (495-1125): 5.14e-20: 99: 9.49		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487850 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59