HitPredict

Interactor 1: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Interactor 2: PHIP (Q8WWQ0)
PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)
Gene: PHIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31911655, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2115 Hs			1 1821
+	Hs
		518903 TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04		PHIP_HUMAN (1-1821): 0: 1502: 100.00
+	Hs
		1061201 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		1061204 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		SNR40_HUMAN (355-666): 5.05e-55: 198: 13.23
+	Hs
		1061156 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		PB1_HUMAN (1116-1652): 2.52e-41: 169: 15.22
+	Hs
		1061226 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		KTNB1_HUMAN (177-396): 6.21e-20: 98.6: 29.73
+	Zm
		5446 A0A1D6DZK4_MAIZE (1170-2069): 4.65e-39: 162: 10.31		A0A1D6FEL1_MAIZE (756-1262): 4.33e-71: 266: 17.31
+	Hs
		903240 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		724952 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		725215 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		1068625 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		1067456 EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		903233 GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		518846 TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		197084 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		PRP4_HUMAN (160-494): 2.06e-16: 86.7: 25.35
+	Hs
		792973 CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63		LIS1_HUMAN (354-552): 3.25e-33: 136: 18.00
+	Mm
		925837 Q155P7_MOUSE (562-1890): 5.59e-30: 133: 11.42		LIS1_MOUSE (354-552): 3.25e-33: 136: 18.00
+	Hs
		254053 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		WDR1_HUMAN (433-682): 6.63e-16: 85.3: 12.22
+	Hs
		728492 MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41		POC1A_HUMAN (20-163): 2.75e-18: 91.5: 10.74