Protein: DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]

Gene: DNA2
Organism: Homo sapiens
Interactions: 64
UniProt ID: P51530

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000729 - DNA double-strand break processing
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

846705

MMS19
MMS19 nucleotide excision repair protein homolog

4

1

Small-scale

0.694

High

282861

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

3

5

High-throughput

0.667

High

846706

DNJC7
DnaJ homolog subfamily C member 7

3

1

High-throughput

0.667

High

210995

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

2

3

High-throughput

0.628

High

846693

TEBP
Prostaglandin E synthase 3

2

3

High-throughput

0.628

High

846701

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

6

High-throughput

0.628

High

846702

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.618

High

282209

SEGN
Secretagogin

2

1

High-throughput

0.611

High

846721

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

1

High-throughput

0.611

High

58222

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

0

High-throughput

0.602

High

610699

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

0

High-throughput

0.602

High

846683

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.602

High

846698

BORA
Protein aurora borealis

2

0

High-throughput

0.602

High

846709

MSTO1
Protein misato homolog 1

2

0

High-throughput

0.602

High

846717

NRBP
Nuclear receptor-binding protein

2

0

High-throughput

0.602

High

846718

AKA11
A-kinase anchor protein 11

2

0

High-throughput

0.602

High

846719

NOB1
RNA-binding protein NOB1

2

0

High-throughput

0.602

High

846686

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.578

High

846722

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.561

High

536333

GLU2B
Glucosidase 2 subunit beta

2

2

High-throughput

0.558

High

846707

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

243336

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.536

High

311678

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

846685

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

846703

TRI52
E3 ubiquitin-protein ligase TRIM52

1

3

High-throughput

0.536

High

846711

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

846712

TTC12
Tetratricopeptide repeat protein 12

1

4

High-throughput

0.536

High

846720

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.536

High

260652

AVIL
Advillin

1

0

High-throughput

0.513

High

280367

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.513

High

574139

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.513

High

846681

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

846704

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

846714

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

846716

DBF4A
Protein DBF4 homolog A

1

0

High-throughput

0.513

High

846680

BLM
RecQ-like DNA helicase BLM

1

7

Small-scale

0.501

High

846692

PLEC
Plectin

1

0

High-throughput

0.493

High

819403

GSH0
Glutamate--cysteine ligase regulatory subunit

1

1

High-throughput

0.489

High

164363

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.479

High

274336

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

8

Small-scale

0.479

High

328778

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.479

High

433654

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.479

High

552268

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

650709

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

720007

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

764345

FEN1
Flap endonuclease 1

1

7

Small-scale

0.479

High

846687

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

2

High-throughput

0.479

High

846688

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

846689

CUL3
Cullin-3

1

8

High-throughput

0.479

High

846690

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

846691

CUL4B
Cullin-4B

1

8

High-throughput

0.479

High

846694

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

846700

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

846710

FACD2
Fanconi anemia group D2 protein

1

5

Small-scale

0.479

High

846713

BRD7
Bromodomain-containing protein 7

1

6

High-throughput

0.479

High

846682

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.458

High

846715

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

373106

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

0

High-throughput

0.328

High

846699

FAT4
Protocadherin Fat 4

2

0

High-throughput

0.328

High

846697

WAC2A
WASH complex subunit 2A

2

0

High-throughput

0.313

High

846696

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

846708

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.279

Low

846684

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.249

Low

846695

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024