HitPredict

Interactor 1: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005198 - structural molecule activity GO:0005886 - plasma membrane GO:0051011 - microtubule minus-end binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2115 Hs			1 7388
+	Hs
		725073 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		1068700 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		110636 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		H3BPE1_HUMAN (66-7004): 0: 1955: 82.41
+	Mm
		513821 PLEC_MOUSE (21-1207): 2.95e-35: 150: 12.47		DMD_MOUSE (69-1516): 9.33e-77: 290: 18.75
+	Hs
		885304 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Hs
		974137 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Mm
		93570 MYH9_MOUSE (1089-2070): 6.61e-40: 165: 12.96		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Mm
		93578 PLEC_MOUSE (21-1207): 2.95e-35: 150: 12.47		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Hs
		724839 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		1068536 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		969584 CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		1137099 CROCC_HUMAN (1-1268): 5.14e-34: 146: 13.75		SYNE1_HUMAN (343-1742): 3.05e-13: 80.2: 8.97
+	Hs
		522612 MYH7_HUMAN (947-2023): 1.11e-36: 155: 11.21		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		724786 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164575 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		724781 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521484 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		724817 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		1045418 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		1059212 GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23