HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: Q5JSZ1 (Q5JSZ1)
TLE family member 4, transcriptional corepressor
Gene: TLE4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 224
+	Mm
		1224207 TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59		TLE4_MOUSE (1-214): 5.3e-120: 360: 92.06
+	Hs
		1047798 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		TLE1_HUMAN (8-214): 2.53e-110: 335: 81.73
+	Hs
		1047795 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		TLE1_HUMAN (8-214): 2.53e-110: 335: 81.73
+	Hs
		1047991 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		Q5JSZ1_HUMAN (1-224): 2.1e-117: 335: 100.00
+	Hs
		1047951 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		TLE3_HUMAN (8-215): 2.08e-100: 309: 74.41
+	Hs
		1047797 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		TLE3_HUMAN (8-215): 2.08e-100: 309: 74.41
+	Hs
		1047950 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		TLE3_HUMAN (8-215): 2.08e-100: 309: 74.41
+	Hs
		1047993 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		Q5T3G3_HUMAN (8-214): 6.02e-102: 296: 81.73
+	Mm
		1224201 TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00		TLE1_MOUSE (8-215): 9.91e-99: 305: 80.38
+	Mm
		988925 TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59		TLE5_MOUSE (8-213): 1.29e-86: 256: 63.11
+	Hs
		1048151 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		TLE5_HUMAN (8-213): 2.02e-86: 255: 63.11
+	Hs
		1047802 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		TLE5_HUMAN (8-213): 2.02e-86: 255: 63.11
+	Hs
		1047891 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		TLE2_HUMAN (8-169): 6.99e-76: 244: 74.69
+	Hs
		1047796 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		TLE2_HUMAN (8-169): 6.99e-76: 244: 74.69
+	Hs
		1047955 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		TLE5_HUMAN (8-213): 2.02e-86: 255: 63.11
+	Mm
		988924 TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00		TLE5_MOUSE (8-213): 1.29e-86: 256: 63.11
+	Hs
		1047890 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		TLE2_HUMAN (8-169): 6.99e-76: 244: 74.69