HitPredict

Interactor 1: G3V7T8 (G3V7T8)
DLG associated protein 3
Gene: Dlgap3

Interactor 2: SHAN3 (Q9JLU4)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	10433269
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0050804 - modulation of chemical synaptic transmission GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Rn			1 1740
+	Mm
		1193777 DLGP3_MOUSE (1-977): 0: 1255: 99.59		SHAN3_MOUSE (1-1740): 1.03e-176: 581: 98.62
+	Hs
		350668 DLGP3_HUMAN (1-977): 0: 1243: 95.00		SHAN3_HUMAN (7-1740): 2.94e-163: 546: 93.61
+	Mm
		1193820 DLGP2_MOUSE (1-977): 0: 1089: 45.30		SHAN3_MOUSE (1-1740): 1.03e-176: 581: 98.62
+	Hs
		350669 DLGP3_HUMAN (1-977): 0: 1243: 95.00		SHAN2_HUMAN (8-1737): 7.95e-120: 420: 40.39
+	Rn
		1021974 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN3_RAT (1-1740): 0: 597: 100.00
+	Mm
		1193934 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN3_MOUSE (1-1740): 1.03e-176: 581: 98.62
+	Hs
		154402 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN3_HUMAN (7-1740): 2.94e-163: 546: 93.61
+	Hs
		1417975 DLGP2_HUMAN (1-977): 0: 1081: 45.61		SHAN3_HUMAN (7-1740): 2.94e-163: 546: 93.61
+	Hs
		154404 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN2_HUMAN (8-1737): 7.95e-120: 420: 40.39
+	Hs
		1454133 DLGP2_HUMAN (1-977): 0: 1081: 45.61		SHAN2_HUMAN (8-1737): 7.95e-120: 420: 40.39
+	Mm
		73163 DLGP4_MOUSE (1-977): 0: 898: 35.71		SHAN3_MOUSE (1-1740): 1.03e-176: 581: 98.62
+	Hs
		1417991 DLGP4_HUMAN (1-977): 0: 887: 35.53		SHAN3_HUMAN (7-1740): 2.94e-163: 546: 93.61
+	Mm
		1243451 DLGP1_MOUSE (1-977): 0: 1055: 37.73		CSKI1_MOUSE (104-1500): 5.53e-105: 371: 16.07
+	Rn
		1021975 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN2_RAT (332-1737): 2.37e-87: 317: 34.61
+	Mm
		1283096 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN2_MOUSE (332-1737): 6.5e-87: 316: 34.37
+	Hs
		1462614 DLGP4_HUMAN (1-977): 0: 887: 35.53		SHAN2_HUMAN (8-1737): 7.95e-120: 420: 40.39
+	Rn
		1021981 DLGP2_RAT (1-977): 0: 1093: 45.58		SHAN1_RAT (439-1735): 1.11e-30: 135: 14.38
+	Rn
		1021976 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN1_RAT (439-1735): 1.11e-30: 135: 14.38
+	Mm
		92686 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN1_MOUSE (439-1735): 3.02e-30: 133: 14.06
+	Hs
		154406 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN1_HUMAN (447-1609): 6.27e-10: 66.8: 11.88