HitPredict

Interactor 1: DLGP2 (Q9P1A6)
Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)
Gene: DLGAP2

Interactor 2: SHAN2 (Q9UPX8)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Gene: SHANK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10527873
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 1849
+	Hs
		1417975 DLGP2_HUMAN (1-1054): 0: 1549: 100.00		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		154404 DLGP1_HUMAN (80-1054): 0: 1202: 52.16		SHAN2_HUMAN (1-1849): 0: 655: 100.00
+	Hs
		350669 DLGP3_HUMAN (80-1054): 0: 1074: 45.72		SHAN2_HUMAN (1-1849): 0: 655: 100.00
+	Mm
		1243451 DLGP1_MOUSE (80-1054): 0: 1180: 51.11		CSKI1_MOUSE (136-1499): 6.32e-156: 519: 14.61
+	Hs
		1462614 DLGP4_HUMAN (80-1054): 0: 955: 42.72		SHAN2_HUMAN (1-1849): 0: 655: 100.00
+	Rn
		1021981 DLGP2_RAT (1-1054): 0: 1482: 89.14		SHAN1_RAT (518-1849): 2.03e-26: 121: 13.24
+	Hs
		154402 DLGP1_HUMAN (80-1054): 0: 1202: 52.16		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Mm
		1193820 DLGP2_MOUSE (1-1054): 0: 1497: 89.14		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43
+	Rn
		1021975 DLGP1_RAT (80-1054): 0: 1184: 51.11		SHAN2_RAT (380-1849): 1.11e-95: 343: 88.20
+	Mm
		1283096 DLGP1_MOUSE (80-1054): 0: 1180: 51.11		SHAN2_MOUSE (380-1849): 2.99e-95: 342: 87.48
+	Hs
		350668 DLGP3_HUMAN (80-1054): 0: 1074: 45.72		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		1417991 DLGP4_HUMAN (80-1054): 0: 955: 42.72		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		154406 DLGP1_HUMAN (80-1054): 0: 1202: 52.16		SHAN1_HUMAN (518-1849): 2.97e-25: 117: 13.75
+	Rn
		1021976 DLGP1_RAT (80-1054): 0: 1184: 51.11		SHAN1_RAT (518-1849): 2.03e-26: 121: 13.24
+	Mm
		92686 DLGP1_MOUSE (80-1054): 0: 1180: 51.11		SHAN1_MOUSE (518-1849): 9.25e-27: 122: 13.46
+	Rn
		1021974 DLGP1_RAT (80-1054): 0: 1184: 51.11		SHAN3_RAT (41-249): 3.74e-15: 83.9: 11.43
+	Mm
		1193934 DLGP1_MOUSE (80-1054): 0: 1180: 51.11		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43
+	Rn
		108170 G3V7T8_RAT (80-1054): 0: 1050: 45.29		SHAN3_RAT (41-249): 3.74e-15: 83.9: 11.43
+	Mm
		1193777 DLGP3_MOUSE (80-1054): 0: 1042: 45.39		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43
+	Mm
		73163 DLGP4_MOUSE (80-1054): 0: 931: 41.99		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43