HitPredict

Interactor 1: CRY1 (Q16526)
Cryptochrome-1
Gene: CRY1

Interactor 2: FBXL3 (Q9UKT7)
F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
Gene: FBXL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	25756610, 17463251, 26186194, 28514442, 27565346, 33961781, 24085301
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0042752 - regulation of circadian rhythm GO:0043153 - entrainment of circadian clock by photoperiod
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 586 Hs			1 428
+	Mm
		956905 CRY1_MOUSE (1-586): 0: 819: 93.23		FBXL3_MOUSE (1-428): 0: 821: 97.20
+	Mm
		956903 CRY1_MOUSE (1-586): 0: 819: 93.23		FXL21_MOUSE (19-428): 0: 721: 75.18
+	Hs
		1082162 CRY1_HUMAN (1-586): 0: 811: 100.00		FXL21_HUMAN (16-428): 0: 713: 72.73
+	Mm
		1207952 CRY2_MOUSE (2-531): 0: 692: 78.11		FBXL3_MOUSE (1-428): 0: 821: 97.20
+	Hs
		1115767 CRY2_HUMAN (3-519): 0: 676: 79.11		FBXL3_HUMAN (1-428): 0: 819: 100.00
+	Mm
		1206353 CRY2_MOUSE (2-531): 0: 692: 78.11		FXL21_MOUSE (19-428): 0: 721: 75.18
+	Hs
		1115766 CRY2_HUMAN (3-519): 0: 676: 79.11		FXL21_HUMAN (16-428): 0: 713: 72.73